873005-49-3

Usage

Uses

Used in Pharmaceutical Industry:
(2-Iodo-4-(trifluoromethyl)phenyl)methanol is used as a synthetic intermediate for the production of pharmaceuticals. Its unique structure and properties make it a valuable building block in the synthesis of a wide range of organic compounds, contributing to the development of new and innovative medications.
Used in Agrochemical Industry:
In the agrochemical sector, (2-Iodo-4-(trifluoromethyl)phenyl)methanol serves as a key intermediate in the synthesis of various agrochemicals. Its role in the production of these chemicals helps to improve agricultural yields and protect crops from pests and diseases.
Used in Organic Compounds and Materials Manufacturing:
(2-Iodo-4-(trifluoromethyl)phenyl)methanol is utilized in the manufacture of organic compounds and materials. Its versatility and reactivity make it an important component in the development of a variety of industrial products, including specialty chemicals and advanced materials.
Handling and Storage:
Due to its high purity and stability, (2-Iodo-4-(trifluoromethyl)phenyl)methanol is typically handled and stored under controlled conditions. This ensures that the compound remains free from degradation and impurities, maintaining its quality and performance in various applications.

Upstream product

• 873006-01-0 2-iodo-4-(trifluoromethyl)benzaldehyde 
• 1383707-89-8 N,N-diethyl-2-iodo-4-(trifluoromethyl)benzamide 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 
• 95725-04-5 N,N-diethyl-4-(trifluoromethyl)benzamide 
• 54507-44-7 2-iodo-4-(trifluoromethyl)benzoic acid 
• 1236303-09-5 methyl 2-iodo-4-(trifluoromethyl)benzoate 
• 61500-87-6 methyl 2-Amino-4-(trifluoromethyl)benzoate 

Downstream Products

• 873006-01-0 2-iodo-4-(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

Iodolopyrazolium Salts: Synthesis, Derivatizations, and Applications

The synthesis of iodolopyrazolium triflates via an oxidative cyclization of 3-(2-iodophenyl)-1H-pyrazoles is described. The reaction is characterized by a broad substrate scope, and various applications of these novel cyclic iodolium salts acting as useful synthetic intermediates are demonstrated, in particular in site-selective ring openings. This was finally applied to generate derivatives of the anti-inflammatory drug celecoxib. Their application as highly active halogen-bond donors is shown as well.

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

Pd-Catalyzed Selective Synthesis of Cyclic Sulfonamides and Sulfinamides Using K2S2O5 as a Sulfur Dioxide Surrogate

A variety of cyclic sulfonamides and sulfinamides could be selectively synthesized under Pd catalysis using haloarenes bearing amino groups and a sulfur dioxide (SO2) surrogate. The amount of base was key in determining the selectivity. Mechanistic studies revealed that sulfinamides were initially formed via an unprecedented formal insertion of sulfur monoxide and were oxidized to sulfonamides in the presence of an iodide ion and DMSO.

Terminal olefins to chromans, isochromans, and pyrans via allylic C-H oxidation

The synthesis of chroman, isochroman, and pyran motifs has been accomplished via a combination of Pd(II)/bis-sulfoxide C-H activation and Lewis acid co-catalysis. A wide range of alcohols are found to be competent nucleophiles for the transformation under uniform conditions (catalyst, solvent, temperature). Mechanistic studies suggest that the reaction proceeds via initial C-H activation followed by a novel inner-sphere functionalization pathway. Consistent with this, the reaction shows reactivity trends orthogonal to those of traditional Pd(0)-catalyzed allylic substitutions.

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.