873017-34-6

Upstream product

• 873017-47-1 [(3S,6S,13S)-3-Methyl-13-((2S,4R)-4-methyl-5-oxo-tetrahydro-furan-2-yl)-2,5-dioxo-1,4-diaza-cyclotridec-6-yl]-carbamic acid tert-butyl ester 
• 106566-02-3 L-valine benzylamide 
• 624743-18-6 N-butoxycarbonyl homoallylglycinal 
• 208522-13-8 (S)-2-N-(tert-butoxycarbonyl)-2-amino-5-hexenoic acid 
• 100-46-9 benzylamine 
• 92136-57-7 (S)-2-tert-butoxycarbonylamino-hex-5-enoic acid methyl ester 
• 67106-22-3 tert-butyl (S)-1-(benzylamino)-3-methyl-1-oxobutan-2-ylcarbamate 
• 93267-04-0 N-(tert-butoxycarbonyl)-L-3-iodoalanine methyl ester 
• 2766-43-0 N-tert-butyloxycarbonyl-L-serine methyl ester 
• 13734-41-3 t-Boc-L-valine 
• 876595-03-8 ((S)-1-{(S)-1-[(S)-1-((2S,4R)-4-Methyl-5-oxo-tetrahydro-furan-2-yl)-pent-4-enylcarbamoyl]-ethylcarbamoyl}-pent-4-enyl)-carbamic acid tert-butyl ester 
• 873017-40-4 (S)-2-((S)-2-tert-Butoxycarbonylamino-hex-5-enoylamino)-propionic acid 
• 208522-14-9 (S)-2-[N⁽²⁾-[(tert-butyloxy)carbonyl]amino]-N-methoxyl-N-methyl-5-hexenoic amide 
• 873017-42-6 (3R,5S)-5-((S)-1-Amino-pent-4-enyl)-3-methyl-dihydro-furan-2-one 

Relevant academic research and scientific papers

Macrocyclic peptidomimetic inhibitors of β-secretase (BACE): First X-ray structure of a macrocyclic peptidomimetic-BACE complex

The synthesis of novel macrocyclic peptidomimetic inhibitors of the enzyme BACE1 is described. These macrocycles are derived from a hydroxyethylene core structure. Compound 7 was co-crystallized with BACE1 and the X-ray structure of the complex elucidated at 1.6 A resolution. This molecule inhibits the production of the Aβ peptide in HEK293 cells overexpressing APP751sw.