873054-59-2

Basic information

• Product Name: N-(4-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• CAS NO: 873054-59-2
• Molecular Weight: 320.391
• Mol File: 873054-59-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(873054-59-2)
• EPA Substance Registry System: N-(4-tert-butylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(873054-59-2)

Safety Data

• Hazardous Substances Data: 873054-59-2(Hazardous Substances Data)

Upstream product

• 769-92-6 4-tert-Butylaniline 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Discovery of N -(2,4-Di- tert -butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, Ivacaftor), a potent and orally bioavailable CFTR potentiator

Quinolinone-3-carboxamide 1, a novel CFTR potentiator, was discovered using high-throughput screening in NIH-3T3 cells expressing the F508del-CFTR mutation. Extensive medicinal chemistry and iterative structure-activity relationship (SAR) studies to evaluate potency, selectivity, and pharmacokinetic properties resulted in the identification of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, 48, ivacaftor), an investigational drug candidate approved by the FDA for the treatment of CF patients 6 years of age and older carrying the G551D mutation.