873054-73-0

Basic information

• Product Name: N-(4-ethylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide
• CAS NO: 873054-73-0
• Molecular Weight: 292.337
• Mol File: 873054-73-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-ethylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-ethylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(873054-73-0)
• EPA Substance Registry System: N-(4-ethylphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide(873054-73-0)

Safety Data

• Hazardous Substances Data: 873054-73-0(Hazardous Substances Data)

Upstream product

• 87-51-4 indole-3-acetic acid 
• 13721-01-2 4-oxo-1,4-dihydroquinoline-3-carboxylic acid 
• 80761-61-1 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid chloride 
• 589-16-2 4-aminoethylbenzene 

Relevant articles and documents

Breaking and Making of Rings: A Method for the Preparation of 4-Quinolone-3-carboxylic Acid Amides and the Expensive Drug Ivacaftor

A simple and convenient method to access 4-quinolone-3-carboxylic acid amides from indole-3-acetic acid amides through one-pot oxidative cleavage of the indole ring followed by condensation (Witkop-Winterfeldt type oxidation) was explored. The scope of the method was confirmed with more than 20 examples and was successfully applied to the synthesis of the drug Ivacaftor, the most expensive drug on the market.