873055-07-3

Usage

Indole derivative

The compound is a derivative of indole, which is a common structural motif in organic chemistry.

Carbonitrile functional group

The compound contains a carbonitrile functional group (CN) on the 2nd carbon atom of the indole ring.

Amino group

The compound has an amino group (NH2) on the 6th carbon atom of the indole ring.

Organic synthesis building block

1H-Indole-2-carbonitrile,6-amino-(9CI) is commonly used as a building block in organic synthesis due to its ability to participate in a variety of chemical reactions.

Pharmaceutical research

The compound has potential applications in the development of pharmaceuticals.

Agrochemical development

1H-Indole-2-carbonitrile,6-amino-(9CI) also has potential applications in the development of agrochemicals.

Versatility

The compound's versatility makes it a valuable tool in the field of organic chemistry.

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Relevant academic research and scientific papers

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.