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Usage

General Description

4-(2-Aminophenyl)benzyl alcohol, also known as 2-APBA, is a chemical compound with the molecular formula C13H13NO. It is often used in the synthesis of various pharmaceuticals and organic compounds. 2-APBA has been studied for its potential use in the development of new drugs, particularly in the treatment of neurological disorders. It has also been used in research as a building block for the synthesis of various organic molecules. The compound is a white solid at room temperature and is soluble in organic solvents such as ethanol and acetone. Its chemical structure consists of a benzyl alcohol molecule with an aminophenyl group attached to the benzene ring, making it a versatile compound for various chemical reactions and applications.

Upstream product

• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 5737-79-1 methyl 2′-amino-[1,1′-biphenyl]-4-carboxylate 
• 615-36-1 2-bromoaniline 

Downstream Products

• 99585-18-9 9H-carbazole-2-carboxaldehyde 

Relevant academic research and scientific papers

Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.

Palladium-Catalyzed Intramolecular C–H Amination in Water

Palladium(II) catalysis was found to be effective for intramolecular C–H amination in water. With 2-azidobiphenyls as substrates, the reaction efficiently provided various carbazoles with N2as the sole byproduct. The reaction showed high functional-group tolerance and could be used in the synthesis of several natural carbazole alkaloids. The catalytic process was promoted by water, and the reaction was inefficient in the organic solvents that were investigated.