99585-18-9Relevant articles and documents
NaI/PPh3-Mediated Photochemical Reduction and Amination of Nitroarenes
Qu, Zhonghua,Chen, Xing,Zhong, Shuai,Deng, Guo-Jun,Huang, Huawen
supporting information, p. 5349 - 5353 (2021/07/21)
A mild transition-metal- and photosensitizer-free photoredox system based on the combination of NaI and PPh3 was found to enable highly selective reduction of nitroarenes. This protocol tolerates a broad range of reducible functional groups such as halogen (Cl, Br, and even I), aldehyde, ketone, carboxyl, and cyano. Moreover, the photoredox catalysis with NaI and stoichiometric PPh3 provides also an alternative entry to Cadogan-type reductive amination when o-nitrobiarenes were used.
The synthesis of a series of fluorescent emitters and their application for dye lasing and cation sensing
Cang, Sheng,Liu, Liang,Tian, Yaqiang,Yang, Zixuan,Zhang, Leiyu
, (2020/10/12)
The following paper reported four carbazole-modified fluorescent emitters. Their molecular structure and electronic transition were analyzed via their single crystal and theoretical calculation. Their photophysical parameters, including absorption, emission and quantum yield, were determined and discussed. It was found that the emission performance of benzo-thiazole-based dyes was better than that of benzo-imidazole-based dyes, owing to the electron-donating effect from the S atom. Upon the presence of metal cations, these photophysical parameters were re-measured. Benzo-thiazole-based dyes were found insensitive towards most metal cations, while benzo-imidazole-based dyes showed obvious photophysical variation upon these metal cations, including absorption red shift and emission quenching. Detailed sensing performance of a representative dye was discussed. A linear working curve with good selectivity was finally observed. Its sensing mechanism was confirmed as the coordination between metal cation and deprotonated benzo-imidazole group. Benzo-thiazole-based dyes showed amplified spontaneous emission (ASE) behavior, with threshold energy of ~220 μJ. Given the optimal condition, a highest ASE efficiency of ~2% was observed, with FWHM value of 6 nm and emission peak of 435 nm. The major novelty and advancement of these fluorescent dyes shall be the stable ASE output (dye 4) under UV excitation and the linear sensing curve with good selectivity (dye 3), which was a hard task for emission turn off sensing probes. We attributed its causation to the valent-recognizing sensing mechanism.
Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility
Sun, Lianqi,Wu, Yanbin,Liu, Yonghua,Chen, Xiaofang,Hu, Laixing
, p. 261 - 265 (2016/12/27)
The current optimization of IG-105 (3) on the carbazole-ring provided a series of new carbazole sulfonamides derivatives 13a–13m. All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of 3 versus HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five (13b, 13g, 13j, 13k and 13l) were found to give IC50values against the four cell lines comparable to those for 3. Two compounds (13f and 13i) were more active than 3 and their activity against HepG2 and MCF-7 (IC50:0.01–0.07?μM) approached that of the positive controls podophyllotoxin (podo) and CA-4. Most of compounds showed aqueous solubility (0.11–19.60?μg/mL at pH 7.4 and 2.0) better than 3. These promising results warrant further development of new compounds 13f and 13i as potential potent antitumor drug candidates.
