873065-70-4Relevant academic research and scientific papers
Novel orally active morpholine N-arylsulfonamides γ-secretase inhibitors with low CYP 3A4 liability
Josien, Hubert,Bara, Thomas,Rajagopalan, Murali,Clader, John W.,Greenlee, William J.,Favreau, Leonard,Hyde, Lynn A.,Nomeir, Amin A.,Parker, Eric M.,Song, Lixin,Zhang, Lili,Zhang, Qi
scheme or table, p. 6032 - 6037 (2010/05/18)
A new class of 2,6-disubstituted morpholine N-arylsulfonamide γ-secretase inhibitors was designed based on the introduction of a morpholine core in lieu or piperidine in our lead series. This resulted in compounds with improved CYP 3A4 profiles. Several a
SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS
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Page/Page column 67, (2010/02/15)
This invention discloses novel gamma secretase inhibitors of the formula I: wherein: L is -O- , -N(R6)-, -S-, -S(O)-, or -S(O2)-; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected f
