873065-92-0

Basic information

• Product Name: Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-
• CAS NO: 873065-92-0
• Molecular Formula: C14H19NO4
• Molecular Weight: 265.309
• Mol File: 873065-92-0.mol

Chemical Properties

• CAS DataBase Reference: Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-(873065-92-0)
• EPA Substance Registry System: Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-(873065-92-0)

Safety Data

• Hazardous Substances Data: 873065-92-0(Hazardous Substances Data)

Upstream product

• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 738624-87-8 1-((4-methoxybenzyloxy)methyl)cyclopropanecarbaldehyde 
• 738624-86-7 (1-((4-methoxybenzyloxy)methyl)cyclopropyl)methanol 
• 39590-81-3 [1-(hydroxymethyl)cyclopropyl]methanol 
• 873065-91-9 5-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)imidazolidine-2,4-dione 

Downstream Products

• 873065-93-1 2-cyclopropyl-2-oxoethyl 2-(tert-butoxycarbonylamino)-2-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)acetate 
• 873065-95-3 2-cyclopropyl-2-oxoethyl 2-(tertbutoxycarbonylamino)-2-(1-((tert-butyldiphenylsilyloxy)methyl)cyclopropyl)acetate 

Relevant articles and documents

Substituted 4-morpholine N-arylsulfonamides as γ-secretase inhibitors

The design, synthesis, SAR, and biological profile of a substituted 4-morpholine sulfonamide series of γ-secretase inhibitors (GSIs) were described. In several cases, the resulting series of GSIs reduced CYP liabilities and improved γ-secretase inhibition activity compared to our previous research series. Selected compounds demonstrated significant reduction of amyloid-β (Aβ) after acute oral dosing in a transgenic animal model of Alzheimer's disease (AD).

SUBSTITUTED N-ARYLSULFONYLHETEROCYCLIC AMINES AS GAMMA-SECRETASE INHIBITORS

This invention discloses novel gamma secretase inhibitors of the formula I: wherein: L is -O- , -N(R6)-, -S-, -S(O)-, or -S(O2)-; R1 is selected from the group consisting of aryl and heteroaryl; R2 is selected f