Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-

Base Information

• Chemical Name: Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-
• CAS No.: 873065-92-0
• Molecular Formula: C14H19NO4
• Molecular Weight: 265.309
• Mol file: 873065-92-0.mol

Synonyms:

Chemical Property of Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]-

There total 6 articles about Cyclopropaneacetic acid, a-amino-1-[[(4-methoxyphenyl)methoxy]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

5-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)imidazolidine-2,4-dione (873065-91-9) → C14H19NO4 (873065-92-0)

Guidance literature:

With barium(II) hydroxide; In water; Reflux;

DOI:10.1016/j.ejmech.2016.08.024

Reference yield:

[1-(hydroxymethyl)cyclopropyl]methanol (39590-81-3) → C14H19NO4 (873065-92-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 6.5 h / 0 - 20 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

2.2: 0.5 h

3.1: triethylamine / ethanol; water / 60 °C / Sonication

4.1: barium(II) hydroxide / water / Reflux

With oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; barium(II) hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Swern Oxidation / 3.1: |Bucherer-Bergs Reaction;

DOI:10.1016/j.ejmech.2016.08.024

Reference yield:

diethyl cyclopropane-1,1-dicarboxylate (1559-02-0) → C14H19NO4 (873065-92-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 6.5 h / 0 - 20 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.17 h / -78 °C

3.2: 0.5 h

4.1: triethylamine / ethanol; water / 60 °C / Sonication

5.1: barium(II) hydroxide / water / Reflux

With lithium aluminium tetrahydride; oxalyl dichloride; sodium hydride; dimethyl sulfoxide; triethylamine; barium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Swern Oxidation / 4.1: |Bucherer-Bergs Reaction;

DOI:10.1016/j.ejmech.2016.08.024

upstream raw materials:

5-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)imidazolidine-2,4-dione

[1-(hydroxymethyl)cyclopropyl]methanol

(1-((4-methoxybenzyloxy)methyl)cyclopropyl)methanol

1-((4-methoxybenzyloxy)methyl)cyclopropanecarbaldehyde

Downstream raw materials:

2-cyclopropyl-2-oxoethyl 2-(tert-butoxycarbonylamino)-2-(1-((4-methoxybenzyloxy)methyl)cyclopropyl)acetate

2-cyclopropyl-2-oxoethyl 2-(tertbutoxycarbonylamino)-2-(1-((tert-butyldiphenylsilyloxy)methyl)cyclopropyl)acetate