87307-75-3

Basic information

• Product Name: 2-(2-(BENZYLOXY)PHENYL)PROPAN-2-OL
• Synonyms: 2-(2-(BENZYLOXY)PHENYL)PROPAN-2-OL
• CAS NO: 87307-75-3
• Molecular Formula: C₁₆H₁₈O₂
• Molecular Weight: 242.316
• Mol File: 87307-75-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-(BENZYLOXY)PHENYL)PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(BENZYLOXY)PHENYL)PROPAN-2-OL(87307-75-3)
• EPA Substance Registry System: 2-(2-(BENZYLOXY)PHENYL)PROPAN-2-OL(87307-75-3)

Safety Data

• Hazardous Substances Data: 87307-75-3(Hazardous Substances Data)

Upstream product

• 620-05-3 iodomethylbenzene 
• 118-93-4 o-hydroxyacetophenone 
• 917-64-6 methyl magnesium iodide 
• 31165-67-0 2'-benzyloxyacetophenone 

Downstream Products

• 85891-85-6 ethyl 3-<4-<2-(phenylmethoxy)phenyl>pyridin-3-yl>propenoate 
• 85891-86-7 ethyl 3-<4-(2-hydroxyphenyl)pyridin-3-yl>propanoate 
• 85891-84-5 4-<2-(phenylmethoxy)phenyl>pyridine-3-carboxaldehyde 
• 85891-87-8 4-<2-(2-ethoxy-2-oxoethoxy)phenyl>-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide 
• 87307-94-6 4-(2-hydroxyphenyl)-1-methyl-3-(3-oxo-3-ethoxypropyl)pyridinium iodide 
• 87307-76-4 ethyl 3-<4-<2-(phenylmethoxy)phenyl>pyridin-3-yl>propanoate 
• 85891-82-3 2-(phenylmethoxy)-α-methylstyrene 

Relevant articles and documents

Synthesis of 3-Methyl-5,6-dihydro-3H-benzofuroisoquinolin-7(7aH)-ones

The coupling of 2-(alkoxymethoxy)phenylcopper derivatives with the salt of ethyl chloroformate and ethyl 3-(pyridin-3-yl)propenoate was found to be an efficient method for the preparation of 4-(2-hydroxyphenyl)pyridines 13 substituted at C-3 with a propanoate side chain.N-Methylation and O-alkylation with ethyl bromoacetate gave salts 3 which when treated with base underwent an intramolecular enolate addition to the pyridinium nucleus to produce spiro 4.Prolonged base treatment of 4 yielded ethyl 3-methyl-7-hydroxy-5,7a-dihydro-3H-benzofuroisoquinoline-6-carboxylates 5 by a Dieckmann reaction.Reduction of 5 led to predominately trans-3-methylhexahydro-1H-benzofuroisoquinolin-7(7aH)-ones, while reduction of 4 and then Dieckmann cyclization yielded mainly the cis isomers.