873107-98-3

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is used as a key intermediate in the synthesis of pharmaceutical compounds for its ability to participate in metal-catalyzed organic reactions. This allows for the creation of new drug molecules with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE serves as a versatile reactant for exploring novel metal-catalyzed organic reactions. Its reactivity and structural features facilitate the development of new synthetic pathways and methodologies, contributing to the advancement of organic chemistry.
Used in Material Science:
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is utilized in the development of new materials with specific properties, such as those with potential applications in electronics, coatings, or other high-tech industries. Its unique structure allows for the creation of materials with tailored characteristics through metal-catalyzed organic reactions.
Used in Agrochemical Industry:
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is employed as a building block in the synthesis of agrochemicals, including pesticides and herbicides. Its involvement in metal-catalyzed organic reactions enables the production of new compounds with improved efficacy and selectivity in agricultural applications.
Overall, 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE is a significant compound in various industries due to its role as a reactant in metal-catalyzed organic reactions, which allows for the synthesis of a wide range of products with diverse applications.

InChI:InChI=1/C6H3F3IN/c7-6(8,9)5-2-1-4(10)3-11-5/h1-3H

Upstream product

• 436799-32-5 5-bromo-2(trifluoromethyl)pyridine 
• 106877-33-2 6-(trifluoromethyl)pyridin-3-amine 

Downstream Products

• 1425511-71-2 3,4-bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine 

Relevant academic research and scientific papers

Rapid Assembly of Saturated Nitrogen Heterocycles in One-Pot: Diazo-Heterocycle “Stitching” by N–H Insertion and Cyclization

Methods that provide rapid access to new heterocyclic structures in biologically relevant chemical space provide important opportunities in drug discovery. Here, a strategy is described for the preparation of 2,2-disubstituted azetidines, pyrrolidines, pi

PYRROLOPYRIMIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula I: [INSERT CHEMICAL FORMULA HERE] wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula I, and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling between Heteroaryl Iodides and α-Chloronitriles

A Ni-catalyzed asymmetric reductive cross-coupling of heteroaryl iodides and α-chloronitriles has been developed. This method furnishes enantioenriched α,α-disubstituted nitriles from simple organohalide building blocks. The reaction tolerates a variety of heterocyclic coupling partners, including pyridines, pyrimidines, quinolines, thiophenes, and piperidines. The reaction proceeds under mild conditions at room temperature and precludes the need to pregenerate organometallic nucleophiles.

DIFLUOROETHYLPYRIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of formula (I) wherein X, Y, Z, R1, R3, R4, R5 and R6 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of formula I.