873112-31-3

Upstream product

• 3187-82-4 (R,R)-N,N′-bis(phenylmethylene)-1,2-cyclohexanediamine 
• 20439-47-8 (1R,2R)-1,2-diaminocyclohexane 
• 100-52-7 benzaldehyde 

Downstream Products

• 873112-39-1 (5,7-dioxa-6-phospha-dibenzo[a,c]cyclohepten-6-yl)-[2-(5-phenyl-imidazol-1-yl)-cyclohexyl]-amine 
• 873112-33-5 C₃₃H₄₀N₃P 
• 873112-32-4 C₂₇H₂₈N₃P 
• 1345265-65-7 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(5-phenyl-1H-imidazol-1-yl)cyclohexyl)thiourea 
• 1345265-81-7 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(5-phenyl-1H-imidazol-1-yl)cyclohexyl)urea 

Relevant academic research and scientific papers

Cooperative thiourea-Bronsted acid organocatalysis: Enantioselective cyanosilylation of aldehydes with TMSCN

We report a new thiourea - Bronsted acid cooperative catalytic system for the enantioselective cyanosilylation of aldehydes with yields up to 90% and enantioselectivities up to 88%. The addition of an achiral acid was found to be crucial for high asymmetric induction. Mechanistic investigations using a combination of NMR, ESI-MS, and density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory suggest that the key catalytic species results from the cooperative interaction of bifunctional thioureas and an achiral acid that form well-defined chiral hydrogen-bonding environments.

Synthesis and asymmetric catalytic application of chiral imidazolium-phosphines derived from (1R,2R)-trans-diaminocyclohexane

Reaction between a chiral imidazole-amine precursor derived from (1R,2R)-trans-diaminocyclohexane and P1Cl (where P1 = PPh2, P(1,3,5-Me3C6H3)2, P(2,2′-O,O′-(1,1′-biphenyl), P((R)