873112-47-1Relevant academic research and scientific papers
Additive-Controlled Divergent Synthesis of Indole and 4 H-Benzo[ d][1,3]oxazine Derivatives: Palladium-Catalyzed Carbonylative Cyclization of 2-Alkynylanilines and Benzyl Chlorides
Wang, Qi,Yao, Lingyun,Wang, Jian-Shu,Ying, Jun,Wu, Xiao-Feng
, p. 3874 - 3882 (2022/02/23)
A palladium-catalyzed divergent carbonylative synthesis of indoles and 4H-benzo[d][1,3]oxazines from 2-alkynylanilines and benzyl chlorides with benzene-1,3,5-triyl triformate (TFBen) as the CO source has been developed. The reaction using AlCl3as the additive produced various indoles in high yields, while a series of 4H-benzo[d][1,3]oxazines was achieved in moderate yields with AcOH as the additive.
Synthesis of ellipticine: A radical cascade protocol to aryl- and heteroaryl-annulated[b]carbazoles
Pedersen, Jan M.,Bowman, W. Russell,Elsegood, Mark R. J.,Fletcher, Anthony J.,Lovell, Peter J.
, p. 10615 - 10618 (2007/10/03)
Imidoyl selanides, synthesized from amides, have been used as radical precursors of imidoyl radicals in cascade reactions. The novel radical cascade has been developed for the simple synthesis of the medicinally important aryl-annulated[b]-carbazoles. The protocol has been exemplified with the high-yielding total synthesis of the anticancer alkaloid ellipticine.
