329937-74-8

Upstream product

• 615-43-0 2-iodophenylamine 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 6265-94-7 2-benzylbenzothiazole 
• 621-72-7 2-benzylbenzimidazole 
• 667408-26-6 methyl 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)acetate 
• 152342-26-2 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)acetic acid 
• 1602747-31-8 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(3,5-di-tert-butylphenyl)acetamide 
• 1602747-25-0 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(5-isopropyl-2-methylphenyl)acetamide 
• 4765-56-4 glycosminine 
• 621-06-7 2,N-diphenylacetamide 
• 1602747-27-2 2-(2-benzyl-1H-benzo[d]imidazol-1-yl)-N-(5-(biphenyl-4-yloxy)-2-fluorophenyl)acetamide 
• 58980-13-5 2-benzyl-4H-3,1-benzoxazine-4-one 
• 115552-48-2 N-carbazolyl-2-phenylacetamide 
• 873112-62-0 (Z)-phenyl 2-phenyl-N-[2-(prop-1-ynyl)phenyl]ethaneselenoimidate 
• 873112-47-1 2-phenyl-N-[2-(2-phenylethynyl)phenyl]acetamide 

Relevant academic research and scientific papers

Discovery of benzimidazole derivatives as modulators of mitochondrial function: A potential treatment for Alzheimer's disease

In this study, we designed a library of compounds based on the structures of well-known ligands of the 18 kDa translocator protein (TSPO), one of the putative components of the mPTP. We performed diverse mitochondrial functional assays to assess their ability to restore cells from Aβ-induced toxicity in vitro and in vivo. Among tested compounds, compound 25 effectively improved cognitive function in animal models of AD. Given the excellent in vitro and in vivo activity and a favorable pharmacokinetic profile of compound 25, we believe that it can serve as a promising lead compound for a potential treatment option for AD.

BENZIMIDAZOLE DERIVATIVES AS MITOCHONDRIAL FUNCTION MODULATORS

Provided are a benzimidazole derivative modulating mitochondrial functions and having pharmaceutical activity as a neuro-protective agent, and a pharmaceutical composition including the compound as an active ingredient.

Synthesis of ellipticine: A radical cascade protocol to aryl- and heteroaryl-annulated[b]carbazoles

Imidoyl selanides, synthesized from amides, have been used as radical precursors of imidoyl radicals in cascade reactions. The novel radical cascade has been developed for the simple synthesis of the medicinally important aryl-annulated[b]-carbazoles. The protocol has been exemplified with the high-yielding total synthesis of the anticancer alkaloid ellipticine.