873206-11-2Relevant academic research and scientific papers
Bicyclic cyanothiazolidines as novel dipeptidyl peptidase 4 inhibitors
Betancort, Juan M.,Winn, David T.,Liu, Ruzhang,Xu, Quansheng,Liu, Junjuan,Liao, Wensheng,Chen, Shu-Hui,Carney, David,Hanway, Denise,Schmeits, James,Li, Xinqiang,Gordon, Eric,Campbell, David A.
, p. 4437 - 4440 (2009)
The synthesis and biochemical evaluation of novel cyanothiazolidine inhibitors of dipeptidyl peptidase 4 (DPP4) is described. Their main structural feature is a constrained bicyclic core that prevents the intramolecular formation of inactive cyclic species. The inhibitors show good to moderate biochemical potency against DPP4 and display distinct selectivity profiles towards DPP7, DPP8 and DPP9 depending on their substitution.
Constrained cyano compounds
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Page/Page column 23, (2010/02/15)
Certain constrained cyano compounds are useful as inhibitors of post-proline/alanine cleaving amino-dipeptidases. Accordingly, these compounds can be employed, alone or with another therapeutic agent, to treat diabetes (especially, Type II diabetes), hyperglycemia, Syndrome X, diabetic complications, hyperinsulinemia, obesity, atherosclerosis and related diseases, as well as various immunomodulatory diseases and chronic inflammatory bowel disease.
