873225-34-4

Basic information

• Product Name: Benzoic acid, 4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]-, methyl ester
• CAS NO: 873225-34-4
• Molecular Formula: C20H15N3O2S
• Molecular Weight: 361.424
• Mol File: 873225-34-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]-, methyl ester(873225-34-4)
• EPA Substance Registry System: Benzoic acid, 4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]-, methyl ester(873225-34-4)

Safety Data

• Hazardous Substances Data: 873225-34-4(Hazardous Substances Data)

Upstream product

• 124959-26-8 4-(2'-benzothienyl)-2-chloropyrimidine 
• 619-45-4 4-methoxycarbonyl aniline 
• 98437-23-1 benzo[b]thiophene-2-boronic acid 

Downstream Products

• 873225-46-8 IKK Inhibitor VII 
• 873225-37-7 4-(4-benzo[b]thiophen-2-yl-pyrimidin-2-ylamino)-benzoyl chloride 

Relevant articles and documents

Design and preparation of 2-benzamido-pyrimidines as inhibitors of IKK

The design, synthesis, and the biological evaluation of 2-benzamido-pyrimidines as novel IKK inhibitors are described. By optimization of the lead compound 3, compounds 16 and 24 are identified as good inhibitors of IKK2 with IC50 values of 40 and 25 nM, respectively. Compound 16 also demonstrated significant in vivo activity in an acute model of cytokine release.