87326-25-8

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
Ethyl 2-methyl-1H-imidazole-4-carboxylate is utilized as a key intermediate in the synthesis of various pharmaceutical agents due to its unique structure and biological activities. It aids in the development of drugs targeting a range of medical conditions.
Used in Cardiovascular Disease Treatment:
In the medical field, Ethyl 2-methyl-1H-imidazole-4-carboxylate is used as a potential therapeutic agent for cardiovascular diseases, leveraging its capacity to influence relevant biological pathways and processes.
Used in Cancer Therapy:
Ethyl 2-methyl-1H-imidazole-4-carboxylate is employed as an oncological treatment option, being studied for its potential to impact the growth and progression of cancer cells, offering a novel approach to cancer management.
Used in Neurological Disorder Management:
Ethyl 2-methyl-1H-imidazole-4-carboxylate also serves as a candidate for the treatment of neurological disorders, given its ability to modulate processes that may be implicated in such conditions, thus offering hope for new therapeutic interventions.
Used in Medicinal Chemistry and Drug Discovery:
Ethyl 2-methyl-1H-imidazole-4-carboxylate is applied as a valuable compound in medicinal chemistry, contributing to the discovery of new drugs and advancing our understanding of molecular interactions related to various diseases.

InChI:InChI=1/C7H10N2O2/c1-3-11-7(10)6-4-8-5(2)9-6/h4H,3H2,1-2H3,(H,8,9)

Upstream product

• 92132-03-1 ethyl 4-amino-2-methylimidazole-5-carboxylate hydrochloride 
• 64-17-5 ethanol 
• 1457-58-5 2-methyl-1H-imidazole-4-carboxylic acid 
• 118493-85-9 acetamide oxime 
• 623-47-2 propynoic acid ethyl ester 
• 35034-22-1 2-methylimidazole-4⁽⁵⁾-carbaldehyde 

Downstream Products

• 131059-75-1 ethyl 1-(2,4-dinitrophenyl)-2-methylimidazole-4-carboxylate 
• 1403332-98-8 Ethyl 1-(2,2-difluoroethyl)-2-methyl-1H-imidazole-4-carboxylate 
• 1403332-87-5 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-isopropyl-2-methyl-1H-imidazole-4-carboxamide 
• 1403332-96-6 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-(2,2-difluoroethyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403333-02-7 N-((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403333-17-4 N-((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((S)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403334-24-6 N-((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 

Relevant academic research and scientific papers

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

IMIDAZOPYRAZINONE DERIVATIVES

Compounds of the formula (I) in which R1 and R2 have the meanings indicated in Claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nerv

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

Synthesis and biological activity of 2-methyl-and 2-bromomethylimidazole nucleosides (1)

The nucleosides of ethyl 2-methylimidazole-4(5)-carboxylate and 2-methylimidazole 4(5)-carboxamide were synthesized by the mercuric cyanide method. The acetylated 2-methyl-4-carboxylate substituted glucoside was also obtained by reductive deamination of the corresponding 5-amino nucleoside derivative. The acetylated 2-methyl-4-carboxylate substituted nucleosides were treated with N-bromosuccinimide to give the corresponding 2-bromomethyl derivatives which showed significant activity gainst HeLa cell cultures. Structural assignments were made on the bases of H 1NMR spectra and, in the some cases, were confirmed by chemical evidence. Nucleosides of 2-methylimidazole-4-carboxamide were tested against type 1 herpes simplex virus and all of them were inactive. The cytostatic activity of the 2-bromomethyl-4-carboxylate substituted nucleosides and the fact that the 2-methyl group of 1-β-D-ribofuranosylimidazole-2-methyl-4-carboxamide causes the loss of antiviral activity are discussed.