87326-25-8

Basic information

• Product Name: Ethyl 2-methyl-1H-imidazole-4-carboxylate
• Synonyms: Ethyl2-methyl-1H-imidazole-4-carboxylate;1H-Imidazole-4-carboxylicacid,2-methyl-,ethylester(9CI);2-Methyl-1H-imidazole-4-carboxylic acid ethyl ester;Ethyl 2-methyl-1H-imidazole-5-carboxylate;2-methyl-1(3)H-imidazole-4-carboxylic acid ethyl ester;2-Methyl-imidazol-5-carbonsaeure-ethylester;ethyl 2-methylimidazole-5-carboxylate
• CAS NO: 87326-25-8
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.17
• Product Categories: GLYCINESCAFFOLD;Heterocycle
• Mol File: 87326-25-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 136-137 °C
• Boiling Point: 339.7 °C at 760 mmHg
• Flash Point: 159.3 °C
• Appearance: /
• Density: 1.171
• Vapor Pressure: 9.01E-05mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.60±0.10(Predicted)
• CAS DataBase Reference: Ethyl 2-methyl-1H-imidazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-methyl-1H-imidazole-4-carboxylate(87326-25-8)
• EPA Substance Registry System: Ethyl 2-methyl-1H-imidazole-4-carboxylate(87326-25-8)

Safety Data

• Hazardous Substances Data: 87326-25-8(Hazardous Substances Data)

Usage

General Description

Ethyl 2-methyl-1H-imidazole-4-carboxylate is a chemical compound with the molecular formula C7H9N3O2. It is a derivative of imidazole and is commonly used in pharmaceutical research and drug development. Ethyl 2-methyl-1H-imidazole-4-carboxylate has been studied for its potential use in the treatment of various medical conditions, including cardiovascular diseases, cancer, and neurological disorders. Ethyl 2-methyl-1H-imidazole-4-carboxylate is known for its ability to modulate biological processes and is of interest to researchers for its potential pharmacological properties. Its unique structure and biological activities make it a valuable compound in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H10N2O2/c1-3-11-7(10)6-4-8-5(2)9-6/h4H,3H2,1-2H3,(H,8,9)

Upstream product

• 118493-85-9 acetamide oxime 
• 623-47-2 propynoic acid ethyl ester 
• 35034-22-1 2-methylimidazole-4⁽⁵⁾-carbaldehyde 
• 64-17-5 ethanol 
• 1457-58-5 2-methyl-1H-imidazole-4-carboxylic acid 
• 92132-03-1 ethyl 4-amino-2-methylimidazole-5-carboxylate hydrochloride 

Downstream Products

• 1403332-98-8 Ethyl 1-(2,2-difluoroethyl)-2-methyl-1H-imidazole-4-carboxylate 
• 1403334-24-6 N-((S)-1-(3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403333-17-4 N-((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((S)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403333-02-7 N-((S)-1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-((R)-2-hydroxypropyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403332-96-6 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-(2,2-difluoroethyl)-2-methyl-1H-imidazole-4-carboxamide 
• 1403332-87-5 (S)-N-(1-(3-(3-Chloro-4-cyano-5-fluorophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-1-isopropyl-2-methyl-1H-imidazole-4-carboxamide 
• 131059-75-1 ethyl 1-(2,4-dinitrophenyl)-2-methylimidazole-4-carboxylate 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof.

LXR MODULATORS

The present invention provides compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as modulators of liver X receptors (LXR), compositions comprising any of such novel compounds, methods of using these compounds or compositions as medicaments for prevention or treatment of diseases or disorders related to liver X receptor (LXR), as well as methods of preparing these LXR modulators and using them in the manufacture of medicaments.

Synthesis and biological activity of 2-methyl-and 2-bromomethylimidazole nucleosides (1)

The nucleosides of ethyl 2-methylimidazole-4(5)-carboxylate and 2-methylimidazole 4(5)-carboxamide were synthesized by the mercuric cyanide method. The acetylated 2-methyl-4-carboxylate substituted glucoside was also obtained by reductive deamination of the corresponding 5-amino nucleoside derivative. The acetylated 2-methyl-4-carboxylate substituted nucleosides were treated with N-bromosuccinimide to give the corresponding 2-bromomethyl derivatives which showed significant activity gainst HeLa cell cultures. Structural assignments were made on the bases of H 1NMR spectra and, in the some cases, were confirmed by chemical evidence. Nucleosides of 2-methylimidazole-4-carboxamide were tested against type 1 herpes simplex virus and all of them were inactive. The cytostatic activity of the 2-bromomethyl-4-carboxylate substituted nucleosides and the fact that the 2-methyl group of 1-β-D-ribofuranosylimidazole-2-methyl-4-carboxamide causes the loss of antiviral activity are discussed.