87327-70-6

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-chloro-6-fluorophenyl)ethan-1-ol is used as a chemical intermediate for the production of antihistamines and muscle relaxants. Its unique chemical structure allows for the creation of these essential medications, which are vital in treating a range of medical conditions.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-chloro-6-fluorophenyl)ethan-1-ol is utilized as a key component in the synthesis of various compounds. Its role in this sector highlights its importance in developing solutions to protect crops and enhance agricultural productivity.
Used as an Antiseptic and Disinfectant:
Leveraging its antimicrobial properties, 1-(2-chloro-6-fluorophenyl)ethan-1-ol is employed as an antiseptic and disinfectant. This application is crucial in maintaining hygiene and preventing the spread of infections in various settings, including healthcare and food processing facilities.
Used in the Chemical Industry:
1-(2-chloro-6-fluorophenyl)ethan-1-ol's versatility extends to the broader chemical industry, where it is used in numerous processes and reactions. Its adaptability makes it a valuable asset in the development and production of a wide array of products.

Upstream product

• 87327-69-3 1-(2-chloro-6-fluorophenyl)ethan-1-one 

Downstream Products

• 1000922-53-1 1-(2-chloro-6-fluorophenyl)ethan-1-amine 

Relevant academic research and scientific papers

ATF6 MODULATORS AND USES THEREOF

Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

Transaminases applied to the synthesis of high added-value enantiopure amines

Critical parameters affecting the stereoselective amination of (hetero)aromatic ketones using transaminases have been studied, such as temperature, pH, substrate concentration, cosolvent, and source and percentage of amino donor, to further optimize the production of enantiopure amines using both (S)- and (R)-selective biocatalysts from commercial suppliers. Interesting enantiopure amino building blocks have been obtained, overcoming some limitations of traditional chemical synthetic methods. Representative processes were scaled up, affording halogenated and heteroaromatic amines in enantiomerically pure form and good isolated yields.

2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES

6-Amino-4-pyrimidinecarboxylic acids having alkyl, alkenyl or alkynyl substituents in the 5-position and 4-aminopicolinic acids having alkyl, alkenyl or alkynyl substituents in the 3-position, and their amine and acid derivatives, are potent herbicides demonstrating a broad spectrum of weed control.

2-(SUBSTITUTED PHENYL)-6-AMINO-5-ALKOXY, THIOALKOXY AND AMINOALKYL-4-PYRIMIDINECARBOXYLATES AND THEIR USE AS HERBICIDES

2-(Substituted phenyl)-6-amino-5-alkoxy, thioalkoxy and aminoalkyl-4-pyrimidinecarboxylic acid and its derivatives are potent herbicides demonstrating broad spectrum of weed control.

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling non-regulated necrosis. This form of cell death can be induced in an array of cell types in apoptotic deficient conditions with death receptor family ligands. A series of [1,2,3]thiadiazole benzylamides was found to be potent necroptosis inhibitors (called necrostatins). A structure-activity relationship study revealed that small cyclic alkyl groups (i.e. cyclopropyl) and 2,6-dihalobenzylamides at the 4- and 5-positions of the [1,2,3]thiadiazole, respectively, were optimal. In addition, when a small alkyl group (i.e. methyl) was present on the benzylic position all the necroptosis inhibitory activity resided with the (S)-enantiomer. Finally, replacement of the [1,2,3]thiadiazole with a variety of thiophene derivatives was tolerated, although some erosion of potency was observed.

2-Ethylsulfonyl pyridine 1-oxide derivatives

Superior herbicidal compounds are provided having the formula: STR1 wherein X and X' are the same or different and are selected from the group consisting of chloro and fluoro.