87331-46-2

Upstream product

• 619-24-9 3-nitrobenzonitrile 
• 873-32-5 2-Chlorobenzonitrile 
• 34662-24-3 3-nitro-2-chlorobenzonitrile 

Downstream Products

• 73629-43-3 3-cyano-benzene-1,2-diamine 
• 1261481-69-9 C₇H₃IN₂O₂ 
• 189125-09-5 2-iodo-3-nitrobenzamide 
• 1431758-05-2 C₁₅H₁₀N₂O₃ 
• 1431758-06-3 C₁₆H₁₂N₂O₃ 
• 1431758-07-4 C₁₆H₁₂N₂O₄ 

Relevant academic research and scientific papers

COMPOUNS, COMPOSITIONS AND METHODS OF USE

Herein, compounds, compositions and methods for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmological diseases, and viral infections are described.

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.

Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides

A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of animation.

Reactions of 3-Amino-2,1-benzothiazole and 3-Aminoindazole with Nitrosonium Hydrogen Sulfate and Nitric Acid in Concentrated Sulfuric Acid

Successive treatment of 3-amino-2,1-benzothiazole in concentrated sulfuric acid by nitrosonium hydrogen sulfate and nitric acid results in formation of 2,1-benzothiazole-3-diazonium ion which undergoes nitration to yield 7-nitro-2,1-benzothiazole-3-diazonium ion as the sole product. A similar reaction with 3-amino-1H-indazole yields preferentially 7-nitro- and 1-nitro-1H-indazole-3-diazonium ions, the 7-nitro isomer prevailing. Nitration of the nondiazotized amines under the same conditions affords mainly corresponding 5-nitro derivatives. The diazonium salts formed as the major and minor products were identified by 13C and 1H NMR spectroscopy and by diazo coupling products.