34662-24-3

Usage

Uses

Used in Dye Industry:
2-Chloro-3-nitrobenzonitrile is used as an intermediate in the synthesis of dyes for various applications, such as textile dyeing and coloring agents in other industries. Its unique chemical structure contributes to the development of dyes with specific color properties and stability.
Used in Pharmaceutical Industry:
2-Chloro-3-nitrobenzonitrile is used as a key intermediate in the production of pharmaceuticals. Its chemical properties allow for the synthesis of various drug molecules, potentially leading to the development of new medications for treating various diseases and conditions.

Upstream product

• 3970-35-2 2-chloro-3-nitrobezoic acid 
• 34128-16-0 2-chloro-3-nitro-benzoyl chloride 
• 143-33-9 sodium cyanide 

Downstream Products

• 1542711-91-0 tert-butyl 2-(2-cyano-6-nitrophenyl)-3-cyclopropyl-3-oxopropanoate 
• 53312-76-8 3-amino-2-chlorobenzonitrile 
• 73629-43-3 3-cyano-benzene-1,2-diamine 
• 200281-35-2 C₇H₉ClN₂ 
• 1261878-28-7 C₇H₇ClN₂O₂ 
• 1301190-00-0 2-({[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}amino)-3-nitrobenzonitrile 
• 1196131-19-7 C₁₁H₁₃N₃O₂ 
• 87331-46-2 2-amino-3-nitrobenzonitrile 
• 359876-76-9 2-amino-4-cyano-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline 
• 359876-78-1 4-cyano-2-nitro-1-N-[1-(3,3-diphenylpropyl)-piperidin-4-yl]aniline 
• 34674-75-4 3-amino-5-nitrobenzo-[b]-thiophene-2-carboxylic acid methyl ester 
• 198961-91-0 4-([3-bromophenyl]amino)-6-nitrobenzothieno[3,2-d]pyrimidine 
• 198961-92-1 6-amino-4-([3-bromophenyl]amino)benzothieno[3,2-d]pyrimidine 
• 3970-35-2 2-chloro-3-nitrobezoic acid 

Relevant academic research and scientific papers

NEW HETEROCYCLIC AMIDES

The present invention relates to new compounds (I) or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.

Tyrosine kinase inhibitors. 16. 6,5,6-Tricyclic benzothieno[3,2-d]pyrimidines and pyrimido[5,4-b]- and -[4,5- b]indoles as potent inhibitors of the epidermal growth factor receptor tyrosine kinase

Several elaborations of the fundamental anilinopyrimidine pharmacophore have been reported as potent and selective inhibitors of the epidermal growth factor receptor (EGFr) tyrosine kinase. This paper reports on a series of inhibitors whereby some 6,5-bicyclic heteroaromatic systems were fused through their C-2 and C-3 positions to this anilinopyrimidine pharmacophore. Although the resulting tricycles did not produce the enormous potency of some of the (5/6),6,6-bicyclic systems, the best of them had IC50s for the EGFr TK around 1 nM. Investigation of 4-position side chains in the indolopyrimidines confirmed that m-bromoaniline was an optimal substituent for potency. Investigation of substitution within the C-(benzo)ring of benzothienopyrimidines confirmed that introduction of an extra ring can change sharply the effects of substituents when compared to similar bicyclic nuclei, and only two substituents were found which even moderately enhanced inhibitory activity over the parent compound for this series.