873310-64-6

Upstream product

• 541-16-2 t-butyl malonate 
• 133464-37-6 (4R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester 
• 133464-36-5 (S)-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester 

Downstream Products

• 873310-65-7 2S-(2-benzyloxycarbonylamino-3-hydroxy-propylidene)-malonic acid di-tert-butyl ester 
• 912354-29-1 (4S)-2-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethyl)malonic acid di-tert-butyl ester 
• 912354-37-1 (2S)-2-(2-benzyloxycarbonylamino-3-hydroxypropyl)malonic acid di-tert-butyl ester 
• 945034-94-6 2-(2-benzyloxycarbonylamino-3-oxo-propyl)-2-tert-butoxycarbonyl-succinic acid di-tert-butyl ester 
• 912354-33-7 (5S)-benzyloxycarbonylamino-3,3-bis-tert-butyloxycarbonyl-6-hydroxyhexanoic acid tert-butyl ester 
• 912354-31-5 (4S)-2,2-dimethyl-4-(2,2,3-tris-tert-butoxycarbonylpropyl)oxazolidine-3-carboxylic acid benzyl ester 
• 912354-35-9 (2S)-benzyloxycarbonylamino-4,4-bis-tert-butyloxycarbonylhexanedioic acid 6-tert-butyl ester 
• 60686-50-2 N-(benzyloxycarbonyl)-γ,γ-di-tert-butyl-L-γ-carboxyglutamic acid 
• 111662-65-8 N-α-(9-fluorenylmethoxycarbonyl)-L-γ-carboxy-glutamic acid-γ,γ-tert-butyl ester 
• 873310-66-8 4-benzyloxycarbonylamino-2-tert-butoxycarbonyl-pent-2-enedioic acid 1-tert-butyl ester 

Relevant academic research and scientific papers

A practical synthesis of fully protected L-γ-carboxyglutamic acid

We have developed a new synthetic route for the preparation of Fmoc protected L-γ-carboxyglutamic acid in 60% overall yield (>99% ee) via a six-step synthesis from D-Garner's aldehyde. An aldol condensation and the selective cleavage of the acetonide prot

Design and concise synthesis of fully protected analogues of L-γ-carboxyglutamic acid

The design and synthesis of four nonnaturally occurring amino acid analogues of L-γ-carboxyglutamic acid (Gla), appropriately protected for Fmoc-based solid-phase peptide synthesis (SPPS), is described. These amino acids are Bu-Mal 2, BCAH 3, Pen-Mal 4, a