873326-65-9

Upstream product

• 160882-76-8 (2S)-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 873326-67-1 (2S,3R,4R)-1-benzyl 2-methyl 3-(2-acetoxyethyl)-4-(tosyloxy)pyrrolidine-1,2-dicarboxylate 
• 873326-68-2 (2S,3R,4R)-1-(benzyloxycarbonyl)-3-(2-hydroxyethyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid 
• 873326-70-6 (2S,3R,4R)-1-benzyl 2-methyl 3-(2-acetoxyethyl)-4-hydroxypyrrolidine-1,2-dicarboxylate 
• 873326-66-0 (2S,3R,4R)-1-benzyl 2-methyl 3-(2-acetoxyethyl)-4-(tosyloxy)pyrrolidine-1,2-dicarboxylate 

Relevant academic research and scientific papers

Stereocontrolled synthesis of (-)-kainic acid from trans-4-hydroxy-L- proline

A highly stereoselective synthesis of (-)-kainic acid has been achieved in 14 steps and > 7% overall yield starting from inexpensive trans-4-hydroxy-L-proline. The key steps are diastereoselective enolate alkylation and cuprate substitution reactions.