873326-66-0

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-3-(2-hydroxyethyl)-, 2-methyl 1-(phenylmethyl) ester, (2S,3R,4R)-
• CAS NO: 873326-66-0
• Molecular Formula: C16H21NO6
• Molecular Weight: 323.346
• Mol File: 873326-66-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-3-(2-hydroxyethyl)-, 2-methyl 1-(phenylmethyl) ester, (2S,3R,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-3-(2-hydroxyethyl)-, 2-methyl 1-(phenylmethyl) ester, (2S,3R,4R)-(873326-66-0)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-3-(2-hydroxyethyl)-, 2-methyl 1-(phenylmethyl) ester, (2S,3R,4R)-(873326-66-0)

Safety Data

• Hazardous Substances Data: 873326-66-0(Hazardous Substances Data)

Upstream product

• 62210-73-5 N-<<(benzyloxy)carbonyl>oxy>-5-norbornene-2,3-dicarboximide 
• 873326-65-9 (2S,3R,4R)-methyl 4-hydroxy-3-(2-hydroxyethyl)-1-(9-phenyl-9H-fluoren-9-yl)pyrrolidine-2-carboxylate 
• 160882-76-8 (2S)-4-oxo-N-(9'-phenylfluoren-9'-yl)pyrrolidine-2-carboxylic acid methyl ester 

Downstream Products

• 873326-67-1 (2S,3R,4R)-1-benzyl 2-methyl 3-(2-acetoxyethyl)-4-(tosyloxy)pyrrolidine-1,2-dicarboxylate 
• 873326-68-2 (2S,3R,4R)-1-(benzyloxycarbonyl)-3-(2-hydroxyethyl)-4-(tosyloxy)pyrrolidine-2-carboxylic acid 

Relevant articles and documents

Stereocontrolled synthesis of (-)-kainic acid from trans-4-hydroxy-L- proline

A highly stereoselective synthesis of (-)-kainic acid has been achieved in 14 steps and > 7% overall yield starting from inexpensive trans-4-hydroxy-L-proline. The key steps are diastereoselective enolate alkylation and cuprate substitution reactions.