873330-06-4

Upstream product

• 1955-46-0 5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester 
• 945019-23-8 C₁₂H₁₆N₂O₃ 
• 329931-92-2 C₁₂H₁₄N₂O₅ 

Downstream Products

• 945019-31-8 C₁₃H₁₄N₂O₃ 
• 945019-25-0 C₁₃H₁₆N₂O₄ 
• 945019-26-1 C₁₅H₂₀N₂O₄ 
• 945019-32-9 C₁₂H₁₂N₂O₃ 
• 945019-28-3 C₁₂H₁₄N₂O₄ 

Relevant academic research and scientific papers

Alpha-helical mimetics

Benzoyl urea derivatives that are alpha helical peptides mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting-moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralizing pro-survival Bcl-2 proteins. Use of benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also described.

Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1

The design and synthesis of a novel series of potent BACE1 hydroxyethylamine inhibitors. These inhibitors feature hydrogen bonding substituents at the C-5 position of the isophthalamide ring with improved selectivity over cathepsin D.

ALPHA-HELICAL MIMETICS

Benzoyl urea derivatives that are alpha helical peptide mimetics that mimic BH3-only proteins, compositions containing them, their conjugation to cell-targeting moieties, and their use in the regulation of cell death are disclosed. The benzoyl urea derivatives are capable of binding to and neutralising pro-survival Bcl-2 proteins. Use of the benzoyl urea derivatives in the treatment and/or prophylaxis of diseases or conditions associated with deregulation of cell death are also disclosed.