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Usage

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 5-bromo-2-ethyl(9CI) is used as an intermediate for the synthesis of pharmaceuticals for its potential role in the development of new drugs with therapeutic properties.
Used in Agricultural Industry:
Pyrimidine, 5-bromo-2-ethyl(9CI) is used as an intermediate for the synthesis of agrochemicals, potentially contributing to the development of new pesticides or other agricultural chemicals.
Used in Academic Research:
Pyrimidine, 5-bromo-2-ethyl(9CI) is used as a building block in the synthesis of various biologically active compounds, facilitating the exploration of new chemical entities and their potential applications in life sciences.

Upstream product

• 60544-11-8 2-ethyl-pyrimidine 
• 557-20-0 diethylzinc 
• 183438-24-6 5-bromo-2-iodopyrimidine 
• 1235450-86-8 5-bromo-2-ethylpyrimidine-4-carboxylic acid 
• 32779-36-5 5-Bromo-2-chloropyrimidine 

Downstream Products

• 1083329-21-8 2-ethyl-5-benzyloxypyrimidine 
• 1351167-69-5 (S)-1-(1-(2-ethylpyrimidin-5-yl)piperidin-4-yl)-3-(2-fluoro-4-(methylsulfonyl)phenylamino)pyrrolidin-2-one 
• 1172612-64-4 C₁₅H₁₄N₂ 
• 1172612-62-2 C₁₄H₁₂N₂ 
• 1172612-63-3 C₁₅H₁₄N₂ 
• 1072855-08-3 (3S)-N,N-dibenzyl-5-(2-ethylpyrimidin-5-yl)chroman-3-amine 

Relevant academic research and scientific papers

Preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine

The invention discloses a preparation method of 2-ethyl-5-(piperidine-4-yl)pyrimidine. A target product is obtained by taking 2-ethyl pyrimidine as a starting raw material through bromine feeding, coupling, elimination and catalytic hydrogenation reaction. The compound is an important medicine intermediate.

PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY

PROBLEM TO BE SOLVED: To provide phosphoinositide 3-kinase inhibitors with a zinc binding moiety. SOLUTION: There is provided a compound represented by formula (I) in the figure. (X is S, O or the like; Y is CH, N or the like; G1 is optionally substituted N or the like; R1 and R2 are each independently H or the like; C is a substituted heterocycle or the like; B is a linear alkyl or the like; Ra and Rb together with the nitrogen atom coupled to them are morpholino or the like; G2 is an indazole ring or the like; q, r and s are independently from 0 to 1, provided that at least one of them is 1; t is from 0 to 1; n is from 0 to 4; and p is from 0 to 2.) COPYRIGHT: (C)2016,JPOandINPIT

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

TREATMENT OF CANCERS HAVING K-RAS MUTATIONS

The present invention provides a method of treating a cancer associated with a K-ras mutation in a subject in need thereof. The method comprises the steps of: (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) administering to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.

TREATMENT OF CANCERS HAVING K-RAS MUTATIONS

The present invention provides a method of treating a cancer associated with a K- ras mutation in a subject in need thereof. The method comprises the steps of (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) adminsiterign to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.

A simple Cu-catalyzed coupling approach to substituted 3-pyridinol and 5-pyrimidinol antioxidants

(Chemical Equation Presented) A convenient approach to 3-pyridinols and 5-pyrimidinols via a two-step Cu-catalyzed benzyloxylation/catalytic hydrogenation sequence is presented. The corresponding 3-pyridinamines and 5-pyrimidinamines can be prepared in an analogous sequence utilizing benzylamine in lieu of benzyl alcohol. The radical-scavenging ability of these derivatives are preliminarily explored and reveal that the increased acidities of the pyridinols and pyrimidinols render them susceptible to more significant kinetic solvent effects when compared to phenols.