873402-73-4

Upstream product

• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 80171-34-2 1-bromo-2-(ethoxymethyl)benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 113245-36-6 α,α'-diethoxy-o-xylene 
• 859781-95-6 2-ethoxymethyl-benzaldehyde diethylacetal 

Downstream Products

• 276888-00-7 indan-2,2-dicarboxylic acid, dimethyl ester 
• 103386-05-6 2-ethoxymethyl-benzyl alcohol 
• 103323-95-1 2-ethoxymethyl-benzoic acid 

Relevant academic research and scientific papers

Divergent Access to Seven/Five-Membered Rings Based on [1,6]-Hydride Shift/Cyclization Process

We have achieved a divergent access to seven/five-membered rings based on a [1,6]-hydride shift/cyclization process from benzylidenemalonate with an o-alkoxymethyl group. Whereas Yb(OTf)3 afforded benzoxepines (with a seven-membered ring) selectively, indanes (with a five-membered ring) were the main products when Sc(OTf)3 was employed.

PROCESS FOR PRODUCING AROMATIC ALDEHYDE

A process for producing an aromatic aldehyde compound represented by a general formula (3): (wherein R' and n are as defined below), which comprises reacting a benzyl compound represented by a general formula (1): (wherein R may represents hydrogen atom, n represents an integer of 1 to 6, and R' may be the same or different and represent a hydrogen atom or an alkyl gorup, an alkyl group or a phenyl group which may have a substituent) with an oxy-compound of bromine represented by the formula (2): ????????MBrOm?????(2) (wherein M represents a hydrogen atom or a metal atom, and m represents an integer of 1 to 3) in the presence of an acid catalyst. According to this method, an aromatic aldehyde compound can be produced in high selectivity by a simple operation without using an expensive catalyst or transition metal.