80171-34-2

Basic information

• Product Name: 1-BROMO-2-(ETHOXYMETHYL)BENZENE
• Synonyms: Benzene, 1-bromo-2-(ethoxymethyl)-
• CAS NO: 80171-34-2
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.1
• Product Categories: alkyl bromide
• Mol File: 80171-34-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-BROMO-2-(ETHOXYMETHYL)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BROMO-2-(ETHOXYMETHYL)BENZENE(80171-34-2)
• EPA Substance Registry System: 1-BROMO-2-(ETHOXYMETHYL)BENZENE(80171-34-2)

Safety Data

• Hazardous Substances Data: 80171-34-2(Hazardous Substances Data)

Usage

Appearance

Colorless to pale yellow liquid The compound has a transparent to slightly colored appearance, with a faint aromatic odor.

Odor

Faint aromatic The compound has a mild, pleasant, and characteristic smell associated with aromatic compounds.

Uses

Intermediate in synthesis 1-Bromo-2-(ethoxymethyl)benzene is used as an intermediate in the production of various organic compounds, including pharmaceuticals, agrochemicals, and other fine chemicals.

Applications

Fragrance ingredients and flavorings The compound is also utilized in the production of fragrances and flavorings for different products.

Hazardous substance

Proper safety precautions required As a hazardous substance, it is essential to follow safety guidelines and precautions when handling and storing 1-Bromo-2-(ethoxymethyl)benzene to minimize potential risks and hazards.

Upstream product

• 64-17-5 ethanol 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 18982-54-2 o-bromobenzyl alcohol 
• 75-03-6 ethyl iodide 

Downstream Products

• 121114-65-6 dichlorobis(2-(ethoxymethyl)phenyl)stannane 
• 121114-68-9 2-(2-(ethoxymethyl)phenyl)-1,3,2-dioxaborolane 
• 276888-00-7 indan-2,2-dicarboxylic acid, dimethyl ester 
• 873402-73-4 2-ethoxymethyl-benzaldehyde 

Relevant articles and documents

Divergent Access to Seven/Five-Membered Rings Based on [1,6]-Hydride Shift/Cyclization Process

We have achieved a divergent access to seven/five-membered rings based on a [1,6]-hydride shift/cyclization process from benzylidenemalonate with an o-alkoxymethyl group. Whereas Yb(OTf)3 afforded benzoxepines (with a seven-membered ring) selectively, indanes (with a five-membered ring) were the main products when Sc(OTf)3 was employed.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aryl halide under conditions suitable to form a Grignard reagent and thereafter contacting the Grignard reagent with an aryl chloride in the presence of a catalyst comprising a nickel compound and a coordinating ligand under conditions suitable for the formation of biaryl compound. In an alternate embodiment of the present invention, biaryl compounds are prepared directly from aryl halides in a single reaction vessel by contacting aryl halide with elemental magnesium and a nickel catalyst comprising a nickel compound and a coordinating ligand in an aprotic, non-polar, ether-containing solvent system for a time and under conditions suitable for the formation of biaryl compound.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.