87342-76-5

Upstream product

• 1073-67-2 4-vinylbenzyl chloride 
• 66977-67-1 3-methylene-1,4-diphenylazetidin-2-one 
• 1137-96-8 N-(benzylidene)aniline N-oxide 
• 98-95-3 nitrobenzene 
• 100-52-7 benzaldehyde 
• 74108-17-1 (3R,4R)-3-[(4-Chloro-phenyl)-hydroxy-methyl]-1,4-diphenyl-azetidin-2-one 
• 104-88-1 4-chlorobenzaldehyde 

Relevant academic research and scientific papers

Stereoselective Synthesis of Ezetimibe via Cross-Metathesis of Homoallylalcohols and α-Methylidene-β-Lactams

Ru-catalyzed cross-metathesis (CM) reaction between β-arylated α-methylidene-β-lactams and terminal olefins was developed. The CM reaction is effectively catalyzed with Hoveyda-Grubbs second-generation catalyst affording corresponding α-alkylidene-β-aryl-

Stereochemistry of Dehydration and Halogenation of αR* and αS* Isomeric 3-(α-Hydroxybenzyl)-1,4-diphenyl-2-azetidinones

Dehydration with p-tosyl chloride in pyridine starting with the αR* isomers of the title compounds 3 results in formation of (E)-3-arylmethylene-β-lactams 4. (Z)-4 is obtained by starting with αS* isomeric 3.Halogenation of αS*-3 with thionyl chloride in chloroform yields αR* halogeno compounds 6 by inversion at C-α, and dehydrohalogenation of 6 by amines results in the specific formation of (E)-4.