873431-68-6Relevant articles and documents
Pulvinones as bacterial cell wall biosynthesis inhibitors
Antane, Schuyler,Caufield, Craig E.,Hu, William,Keeney, David,Labthavikul, Pornpen,Morris, Koi,Naughton, Shaughnessy M.,Petersen, Peter J.,Rasmussen, Beth A.,Singh, Guy,Yang, Youjun
, p. 176 - 180 (2007/10/03)
Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA-MurD. Several pulvinones inhibited Mur enzymes with IC50's in the 1-10 μg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.