69556-70-3Relevant articles and documents
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Kumler
, p. 2532 (1938)
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Lewis Acid Mediated Addition of Indoles and Alcohols to Tetronic Acid and Tetramic Acids
Banales Mejia, Fernando,Lafferty, Megan M.,Melvin, Sophia J.,Truax, Nathanyal J.,Kean, Maeve H.,Pelkey, Erin T.
, p. 260 - 264 (2017)
The electrophilic substitution of indoles with tetronic acid and N-acetyltetramic acid mediated by BF3·OEt2 was investigated. This strategy allowed for the preparation of nine indole-substituted furan-2-ones (indolyl-γ-lactones) and 3-pyrrolin-2-ones (indolyl-γ-lactams) and is more straightforward than previously reported synthetic methods. During the course of our investigation, we also discovered a facile synthesis of tetronates and a tetramate via a BF3-mediated addition of alcohols to tetronic acid and N-acetyltetramic acid, respectively.
Methyl (E)-4-chloro-3-methoxy-2-butenoate: An extremely versatile four carbon building block
Duc,McGarrity,Meul,Warm
, p. 391 - 394 (2007/10/02)
Methyl (E)-4-chloro-3-methoxy-2-butenoate (3a) is inexpensively prepared from methyl 4-chloroacetoacetate using thionyl chloride and methanol on an industrial scale. Many nucleophilic substitution reactions of chloride, which are impossible with the unpro