69556-70-3

Usage

Uses

Used in Chemical Synthesis:
4-Methoxy-2(5H)-furanone is used as a starting reagent in the synthesis of 5-alkylidene 4-methoxy-2(5H)-furanone. 4-METHOXY-2(5H)-FURANONE is an important intermediate in the production of various chemical compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-Methoxy-2(5H)-furanone is used as a building block for the development of new drugs. Its unique structure and properties make it a promising candidate for the synthesis of novel therapeutic agents with potential applications in various medical fields.
Used in Agrochemical Industry:
4-Methoxy-2(5H)-furanone is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its unique chemical properties allow for the development of innovative products that can help address various agricultural challenges.
Used in Flavor and Fragrance Industry:
Due to its distinctive aroma and flavor profile, 4-Methoxy-2(5H)-furanone is used in the flavor and fragrance industry as a key ingredient in the creation of various scents and flavors. Its unique properties make it a valuable component in the development of new and innovative products in this industry.

InChI:InChI=1/C5H6O3/c1-7-4-2-5(6)8-3-4/h2H,3H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 4971-56-6 tetrahydrofuran-2,4-dione 
• 1445-45-0 Trimethyl orthoacetate 
• 86268-15-7 methyl 5-lithiotetronate 
• 1116-51-4 ethyl χ-bromo-β-methoxycrotonate 
• 707-07-3 orthobenzoic acid trimethyl ester 
• 67-56-1 methanol 
• 3510-99-4 3-methoxy-but-2-enoic acid ethyl ester 
• 110104-60-4 (E)-4-chloro-3-methoxy-but-2-enoic acid methyl ester 
• 69945-03-5 Methoxymaleinsaeureanhydrid 
• 541-57-1 4-hydroxy-2(5H)-furanone 

Downstream Products

• 345620-82-8 methyl 5-(1'-hydroxy-3'-phenylpropyl)tetronate 
• 72168-21-9 4-methoxy-5-(1-methoxy-3-phenyl-allyl)-5H-furan-2-one 
• 68776-83-0 4-Methoxy-5-((E)-1-methoxy-3-phenyl-allyl)-5H-furan-2-one 
• 82204-21-5 methyl 5-(1-methoxybenzyl)tetronate 
• 78376-11-1 (5RS)-5-[(RS/SR)-1-hydroxybenzyl]-4-methoxyfuran-2(5H)-one 
• 344257-47-2 5-(1-Hydroxy-1-phenyl-ethyl)-4-methoxy-5H-furan-2-one 
• 30290-18-7 4-(methylamino)furan-2(5H)-one 
• 38470-54-1 4-benzylamino-2(5H)-furanone 
• 82204-20-4 methyl 5-(1',1'-dimethoxybenzyl)tetronate 
• 541-57-1 4-hydroxy-2(5H)-furanone 
• 873431-60-8 5-[hydroxy-(3-trifluoromethyl-phenyl)-methyl]-4-methoxy-5H-furan-2-one 
• 873431-70-0 5-[(4-chloro-phenyl)-hydroxy-methyl]-4-methoxy-5H-furan-2-one 
• 873431-55-1 5-(cyclohexyl-hydroxy-methyl)-4-methoxy-5H-furan-2-one 

Relevant academic research and scientific papers

Pseudoesters and derivatives xxxvi. reactions of enolates of 5-ethylthiofuran-2(5h)-ones with aromatic aldehydes: A synthesis of losigamone

The furanones (3a) and (3b), key intermediates in our approach to losigamone (12), have been prepared by reaction of 2-chlorobenzaldehyde with the enolates (2A) and (2B) of the corresponding tetronic acid derivatives (2a) and (2b). The reductiv

Lewis Acid Mediated Addition of Indoles and Alcohols to Tetronic Acid and Tetramic Acids

The electrophilic substitution of indoles with tetronic acid and N-acetyltetramic acid mediated by BF3·OEt2 was investigated. This strategy allowed for the preparation of nine indole-substituted furan-2-ones (indolyl-γ-lactones) and 3-pyrrolin-2-ones (indolyl-γ-lactams) and is more straightforward than previously reported synthetic methods. During the course of our investigation, we also discovered a facile synthesis of tetronates and a tetramate via a BF3-mediated addition of alcohols to tetronic acid and N-acetyltetramic acid, respectively.

Highly efficient 4-O-alkylations of tetronic acids involving oxyphosphonium intermediates

4-Alkoxy-5H-furan-2-ones were prepared in fair to high yields by regioselective 4-O-alkylation of tetronic acids with stoichiometric amounts of primary and secondary alcohols. This approach involves the intermediacy of (5-oxo-2,5-dihydrofuran-3-yloxy) phosphonium trifluoromethanesulfonates, which were generated in situ on reaction of tetronic acids with triphenylphosphonium anhydride trifluoromethanesulfonate (Hendrickson's reagent).

Methyl (E)-4-chloro-3-methoxy-2-butenoate: An extremely versatile four carbon building block

Methyl (E)-4-chloro-3-methoxy-2-butenoate (3a) is inexpensively prepared from methyl 4-chloroacetoacetate using thionyl chloride and methanol on an industrial scale. Many nucleophilic substitution reactions of chloride, which are impossible with the unpro

Synthetic Routs to the Piperolides, Faydenolides, Epoxypiperolides, and Related Compounds

Syntheses of the piperolides, the faydenolides, epoxypiperolide, and related compounds are described. (+/-)-Narthogenin is also efficiently produced.

Regioselectivity control in metal hydride reductions of substituted maleic anhydrides

A systematic study of reductions of unsymmetrically substituted maleic anhydrides by a variety of metal hydride reagents indicates that the high regioselectivity observed in these reactions is controlled chiefly by electronic factors.

Reaction of Methyl Tetronate with some Amines. Synthesis of Substituted 4-Aminobut-2-enolides

A series of substituted 4-aminobut-2-enolide derivatives have been synthesized by reaction of a variety of substituted amines with methyl tetronate.The (1)H and (13)C nmr spectral analysis of all compounds synthesized are given.