87346-53-0

Upstream product

• 77-78-1 dimethyl sulfate 
• 262589-79-7 3-chlorosulfonyl-4-methoxybenzoic acid ethyl ester 
• 651729-63-4 3-chlorosulfonyl-4-methoxy-benzoyl chloride 
• 50803-29-7 3-chlorosulfonyl-4-methoxybenzoic acid 
• 67745-31-7 3-mercapto-4-methoxy-benzoic acid 

Downstream Products

• 213598-13-1 4-methoxy-3-methylsulfonylbenzoic acid 
• 262589-81-1 4-hydroxy-3-methylsulfanylbenzoic acid 
• 262589-83-3 4-hydroxymethyl-2-methylsulfanylphenol 
• 262589-71-9 4-[4-(4-fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-2-ylsulfanylmethyl]-2-methylsulfanyl-phenol 

Relevant academic research and scientific papers

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Imidazole inhibitors of cytokine release: Probing substituents in the 2 position

Novel 2,4,5-trisubstituted imidazole derivatives were prepared as potential anticytokine agents. Thirty-seven compounds were tested on their ability to inhibit the release of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) from peripheral blood