87349-92-6

Basic information

• Product Name: 2,3,5,6-1H,4H-Tetrahydro-9-(3-pyridyl)quinolizino[9,9a,1-gh]coumarin
• Synonyms: Exciton Coumarin 510;10-(3-Pyridyl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizine-11-one;10-(Pyridin-3-yl)-2,3,6,7-tetrahydro-1H,5H,11H-[1]benzopyrano[6,7,8-ij]quinolizin-11-one
• CAS NO: 87349-92-6
• Molecular Formula: C20H18N2O2
• Molecular Weight: 318.37
• Mol File: 87349-92-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 163.0 to 167.0 °C
• Boiling Point: 596.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 5.44±0.40(Predicted)
• CAS DataBase Reference: 2,3,5,6-1H,4H-Tetrahydro-9-(3-pyridyl)quinolizino[9,9a,1-gh]coumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5,6-1H,4H-Tetrahydro-9-(3-pyridyl)quinolizino[9,9a,1-gh]coumarin(87349-92-6)
• EPA Substance Registry System: 2,3,5,6-1H,4H-Tetrahydro-9-(3-pyridyl)quinolizino[9,9a,1-gh]coumarin(87349-92-6)

Safety Data

• Hazardous Substances Data: 87349-92-6(Hazardous Substances Data)

Usage

General Description

2,3,5,6-1H,4H-Tetrahydro-9-(3-pyridyl)quinolizino[9,9a,1-gh]coumarin, also known as TC-1, is a chemical compound that belongs to the class of coumarins and quinoline derivatives. It is a synthetic cannabinoid receptor agonist, meaning it has the ability to bind to and activate cannabinoid receptors in the brain and body. TC-1 is commonly used in scientific research to study the effects of cannabinoid receptor activation, particularly in the context of pain management and neuroprotection. It has also been studied for its potential therapeutic applications in various neurodegenerative disorders. Additionally, TC-1 may have psychoactive effects and is considered a controlled substance in many jurisdictions.

Upstream product

• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 63149-33-7 9-formyl-8-hydroxyjulolidine 
• 41175-50-2 8-hydroxyjulolidine 

Relevant articles and documents

Rapid detection of nerve agents in environmental and biological samples using a fluorescent probe

Nerve agents are highly toxic chemical warfare agents that are easy to synthesize and have recently been applied many times in local wars and terrorist attacks. Fluorescent probes have been widely used in life science and medical research due to their features of short reaction time, high sensitivity and good selectivity. Herein, two fluorescent compounds, NMU-1 and NMU-2, were synthesized for the selective detection of nerve agents. NMU-1 exhibited good detection performance for nerve agents. With increasing nerve agent concentration, the fluorescence signal of NMU-1 at 498 nm gradually decreased with an excellent linear relationship. NMU-1 exhibited a low LOD (4.6 μM for DCP and 8.41 μM for soman), a rapid response (less than 3 min) and a large Stokes shift (98 nm) along with obvious color changes. Due to its high sensitivity and good selectivity, NMU-1 was successfully applied to image nerve agents in living PC12 cells. Furthermore, NMU-1 was used as a key element to develop chemical warfare agent test paper, which exhibited significant fluorescent changes under hand-held 365-nm UV light upon contact with nerve agents.