87351-05-1Relevant academic research and scientific papers
Desulfitative Pd-catalysed coupling reaction using benzenesulfonyl chlorides and enones as the coupling partners
Yuan, Kedong,Sang, Rui,Soulé, Jean-Fran?ois,Doucet, Henri
, p. 2904 - 2912 (2015/05/20)
The reaction of benzenesulfonyl chlorides with enones was investigated. β-Ionone and benzalacetone in the presence of a palladium catalyst were found to afford the conjugate addition products instead of the expected Heck type products. The reaction tolerates a wide variety of substituents on the benzenesulfonyl chloride. It should be noted that no cleavage of the C-Br and C-I bonds was observed in the course of the reactions with 4-bromo- or 4-iodo-benzenesulfonyl chlorides, allowing further transformations. For example, using 4-bromobenzenesulfonyl chloride as the central unit, consecutive conjugate addition following arylations allowed access to substituted bi(hetero)aryls.
Palladium-catalyzed direct 1,4-addition of heteroarenes to α,β-unsaturated ketones via C-H activation
Zhang, Xuan,Yu, Xiaoqiang,Feng, Xiujuan,Bao, Ming
supporting information; experimental part, p. 1605 - 1608 (2012/08/07)
Palladium-catalyzed direct conjugate additions of heteroarenes to α,β-unsaturated ketones via C-H activation are described. The reactions of heteroarenes with α,β-unsaturated ketones proceeded smoothly in the presence of PdClas a catalyst under mild conditions to give the corresponding Michael adducts in moderate to excellent yields. Georg Thieme Verlag Stuttgart · New York.
Palladium-Catalyzed Conjugate Addition Type Reaction of Aryl Iodides with α,β-Unsaturated Ketones
Cacchi, S.,Arcadi, A.
, p. 4236 - 4240 (2007/10/02)
Aryl iodides have been found to react with α,β-unsaturated ketones in the presence of catalytic amounts of palladium, an excess of formic acid, and triethylamine, giving rise to conjugate addition type products.The electron-withdrawing power of the group attached to the olefinic double bond, the substituent β to the carbonyl group, and the basic reaction medium appear to effect greatly the conjugate addition/vinylic substitution ratio.
