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Tert-butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate is a versatile chemical compound belonging to the class of dihydropyridines. It is a derivative of pyridine, featuring a tert-butyl group and a cyano group, which contribute to its unique chemical properties and potential applications in various fields.

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  • SAGECHEM/tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate/SAGECHEM/Manufacturer in China

    Cas No: 873551-20-3

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  • 873551-20-3 Structure
  • Basic information

    1. Product Name: tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate
    2. Synonyms: tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate
    3. CAS NO:873551-20-3
    4. Molecular Formula: C11H16N2O2
    5. Molecular Weight: 208.25694
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 873551-20-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate(873551-20-3)
    11. EPA Substance Registry System: tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate(873551-20-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 873551-20-3(Hazardous Substances Data)

873551-20-3 Usage

Uses

Used in Pharmaceutical Synthesis:
Tert-butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Synthesis:
In the agrochemical industry, tert-butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate is utilized as an intermediate in the production of agrochemicals, potentially enhancing crop protection and yield.
Used in Cardiovascular Disease Treatment:
Tert-butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate is studied for its potential use in the treatment of cardiovascular diseases, due to its calcium channel blocking properties, which may help in managing conditions such as hypertension and angina.
Used in Neurodegenerative Disorder Treatment:
tert-Butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate is also being investigated for its potential role in treating neurodegenerative disorders, possibly due to its antioxidant properties, which could protect neurons from oxidative stress-related damage.
Used in Chemical Research:
Tert-butyl 4-cyano-5,6-dihydropyridine-1(2H)-carboxylate serves as a valuable compound in chemical research, providing insights into the structure-activity relationships of dihydropyridines and their derivatives, which can lead to the discovery of new chemical entities with improved pharmacological profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 873551-20-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,5,5 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 873551-20:
(8*8)+(7*7)+(6*3)+(5*5)+(4*5)+(3*1)+(2*2)+(1*0)=183
183 % 10 = 3
So 873551-20-3 is a valid CAS Registry Number.

873551-20-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-cyano-3,6-dihydro-2H-pyridine-1-carboxylate

1.2 Other means of identification

Product number -
Other names tert-butyl 4-cyano-3,6-dihydropyridine-1(2H)-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:873551-20-3 SDS

873551-20-3Relevant articles and documents

Palladium-Catalyzed α,β-Dehydrogenation of Esters and Nitriles

Chen, Yifeng,Romaire, Justin P.,Newhouse, Timothy R.

supporting information, p. 5875 - 5878 (2015/05/27)

A highly practical and general palladium-catalyzed methodology for the α,β-dehydrogenation of esters and nitriles is reported. Generation of a zinc enolate or (cyanoalkyl)zinc species followed by the addition of an allyl oxidant and a palladium catalyst results in synthetically useful yields of α,β-unsaturated esters, lactones, and nitriles. Preliminary mechanistic investigations are consistent with reversible β-hydride elimination and turnover-limiting, propene-forming reductive elimination.

MICROBIOCIDAL PYRAZOLE DERIVATIVES

-

Paragraph 0146, (2015/02/19)

Compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides.

MICROBIOCIDAL PYRAZOLE DERIVATIVES

-

Page/Page column 31, (2013/09/12)

Compounds of the formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides.

CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS

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Page/Page column 112, (2013/04/10)

Cycloalkylnitrile pyrazole carboxamides as JAK inhibitors useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer are provided.

BIARYL DERIVATIVES

-

Page/Page column 46, (2010/11/26)

The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, whrein: R 1 is a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; R 2 is halogen atom, a lower alkyl group, etc.; Q 1 is carbon atom or nitrogen atom; Q 2 is carbon atom which may be substituted with oxo group; the formula (III) : is a single bond or a double bond; A is a group selected from the group consisting of the substituent group ±; and R 5 is hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

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