873556-49-1

Basic information

• Product Name: 5'-O-(N-(2-benzyloxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine
• Synonyms: 5'-O-(N-(2-benzyloxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine
• CAS NO: 873556-49-1
• Molecular Weight: 582.637
• Mol File: 873556-49-1.mol

Chemical Properties

• CAS DataBase Reference: 5'-O-(N-(2-benzyloxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-O-(N-(2-benzyloxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine(873556-49-1)
• EPA Substance Registry System: 5'-O-(N-(2-benzyloxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine(873556-49-1)

Safety Data

• Hazardous Substances Data: 873556-49-1(Hazardous Substances Data)

Upstream product

• 873556-35-5 ((3aR,4R,6R,6aR)-6-(6-((tert-butoxycarbonyl)amino)-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate 
• 103633-30-3 2-bromomethylphenyl benzyl ether 
• 5896-17-3 2-(phenylmethoxy)benzaldehyde 
• 100-39-0 benzyl bromide 
• 3381-87-1 2-benzyloxybenzyl alcohol 
• 89-95-2 2-methyl-benzyl alcohol 
• 112921-00-3 ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate 

Downstream Products

• 873556-50-4 5'-O-(N-(2-hydroxybenzyl)sulfamoyl)-2',3'-O-isopropylideneadenosine 

Relevant articles and documents

Antibacterial Agents

The invention provides compounds of formula (I) and salts thereof: R1-L-R2—B wherein R1, L, R2, and B have any of the values defined herein, as well as compositions comprising such compounds, and therapeutic methods comprising the administration of such compounds or salts. The compounds block siderophore production in bacteria and are useful as antibacterial agents.

Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in