873571-27-8Relevant academic research and scientific papers
Synthesis of new tetracyclic benzodiazepine-fused isoindolinones using recyclable mesoporous silica nanoparticles
Yuan, Shuo,Yue, Ya-Le,Zhang, Dan-Qing,Zhang, Jing-Ya,Yu, Bin,Liu, Hong-Min
, p. 11461 - 11464 (2020)
Pseudo natural products (NPs) feature structural novelty and diversity and thus are a new source of lead compounds for drug discovery. We first report the mesoporous silica nanoparticles (MSNs)-catalyzed de novo combination of benzodiazepine and isoindolinone, giving tetracyclic benzodiazepine-fused isoindolinone pseudo natural products (21 examples, 55-91% yields). The work also demonstrates that MSNs are efficient acidic catalysts for multi-component reactions.
An approach to dihydroisoindolobenzodiazepinones - Three-dimensional molecular frameworks
Yaremenko, Anatoliy G.,Shelyakin, Vyacheslav V.,Volochnyuk, Dmitriy M.,Rusanov, Eduard B.,Grygorenko, Oleksandr O.
supporting information, p. 1195 - 1197 (2013/03/13)
A concise two-step procedure is developed for the preparation of dihydroisoindolobenzodiazepinones, which represent derivatives of three-dimensional molecular frameworks derived from classical privileged structures of medicinal chemistry. The method commences from the readily available starting materials (i.e., 2-formylbenzoic acid, o-phenylenediamine, and various ketones) and enables the synthesis of the title compounds in 58-82% overall yields.
