873585-83-2Relevant academic research and scientific papers
Palladium(0)-catalyzed synthesis of chiral ene-allenes using alkenyl trifluoroborates
Molander, Gary A.,Sommers, Erin M.,Baker, Sharon R.
, p. 1563 - 1568 (2007/10/03)
Enantioenriched allenes serve as chiral transfer reagents, making them attractive synthetic targets. Herein, the synthesis of enantioenriched allenes utilizing a Pd(0)-catalyzed cross-coupling reaction of propargylic carbonates and phosphates with alkenyl trifluoroborates is reported. Di-, tri-, and tetrasubstituted allenes were synthesized in moderate to high optical yields. Several racemic allenes possessing various functional groups were also synthesized.
