87359-58-8Relevant academic research and scientific papers
(13)C NMR Studies of Tautomerism in Imidazopyridines
Barraclough, P.,Lindon, J. C.,Nobbs, M. S.,Williams, J. M.
, p. 992 - 994 (1989)
A detailed analysis of the (13)C NMR spectra of the 1-N and 3-N-methyl derivatives of 1H-2-(2,4-dimethoxyphenyl)imidazopyridine, utilizing long-range couplings and 2D (1)H-(13)C correlation experiments, has led to an unambiguous assignment of all c
Inotropic activity of heterocyclic analogues of isomazole
Barraclough, P.,Beams, R. M.,Black, J. W.,Cambridge, D.,Collard, D.,et al.
, p. 467 - 477 (2007/10/02)
Aryl-substituted benzimidazole, imidazopyridine, imidazopyrazine, imidazopyridazine, oxazolopyridine, purine, pyrollopyridine and thiazolopyridine derivatives have been prepared and evaluated as inotropic agents.Purine 8 and the 1H-imidazo- and pyridazines 9 and 10 proved to be of most interest, having similar in vivo inotropic potencies to sulmazole.The pKa's, protonation sites and lipophilicities for most heterocycles were determined experimentally and some of their electronic properties calculated.For a subset of active heterocycles a correlation was observed between in vitro inotropism and the charge density of the imidazo nitrogen adjacent to the electrostatic potential minimum.Structure-activity relationships are discussed in some detail.
