1796-73-2

Upstream product

• 1796-82-3 N-methyl-4-nitro-3-pyridineamine 1-oxide 
• 2402-97-3 3-bromopyridine N-oxide 
• 1678-49-5 3-Bromo-4-nitropyridine N-oxide 
• 221636-01-7 3-(methylamino)-4-nitropyridine 
• 76439-45-7 3-chloro-4-nitropyridine N-oxide 

Downstream Products

• 52538-09-7 2,3-dimethylimidazo<4,5-c>pyridine 
• 143361-86-8 4-(3-Methyl-3H-imidazo[4,5-c]pyridin-2-yl)-phenylamine 
• 7322-04-5 3-methylimidazo<4,5-c>pyridine 
• 87359-58-8 2-(2,4-dimethoxyphenyl)-3-methylimidazo<4,5-c>pyridine hydrochloride 
• 146950-63-2 4-methyl-2,3(1H)-dioxo-pyrazino-[5,6-c]pyridine 
• 35251-84-4 1,4-dihydro-pyrido[3,4-b]pyrazine-2,3-dione 

Relevant academic research and scientific papers

BICYCLIC COMPOUNDS

Disclosed herein are nitrogen-containing bicyclic compounds, together with pharmaceutical compositions and methods of ameliorating and/or treating a cancer described herein with one or more of the compounds described herein.

3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: A novel series of mGluR2 positive allosteric modulators

The synthesis and structure-activity relationship (SAR) of a novel series of 3-(imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers, derived from a high throughput screening (HTS), are described. Subsequent optimization led to identification of potent, metabolically stable and orally available mGluR2 positive allosteric modulators (PAMs).

NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS

There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A'): wherein X is a carbon and X is an oxygen, a sulfur or - NR -,or formula (A"): wherein X is a nitrogen and R is an optionally substituted hydrocarbyl, Ris an amino substituted by two optionally substituted hydrocarbyl groups, Ris an phenyl, Y is CR or a nitrogen, Y is CRor a nitrogen and Yis CRor a nitrogen, provided that one or less of Y, Y, and Y is nitrogen, W is a bond, -(CH2)n-, and Z is a bond, -NR -,etc.; or a salt thereof or a prodrug thereof.

HIGH OXIDIZING ACTIVITY OF 8-AZA-3,10-DIMETHYLISOALLOXAZINE (8-AZAFLAVIN)

8-Azaflavin was synthesized for the first time, and it was found that 8-azaflavin is much more reactive (>1E4) than 3,10-dimethylisoalloxazine for oxidation of thiols in aqueous solution.Catalytic efficiency for disulfides synthesis was also examined under aerobic conditions.