873656-92-9

Upstream product

• 161117-84-6 tert-butyl 2-iodophenylcarbamate 

Downstream Products

• 888732-07-8 2-(1-acetoxy-2,3-butadien-2-yl)-N-(tert-butoxycarbonyl)aniline 
• 888732-06-7 N-(tert-butoxycarbonyl)-2-(1-methanesulfonyloxy-2,3-butadien-2-yl)aniline 
• 958882-75-2 N-(tert-butoxycarbonyl)-2-(1-hydroxy-2,3-butadien-2-yl)aniline 
• 914349-13-6 1-(tert-butoxycarbonyl)-3-hydroxymethyl-2-methylindole 

Relevant academic research and scientific papers

A new entry to the synthesis of 2,3-disubstituted indoles

(Chemical Equation Presented) The Stille coupling of N-acyl-2-iodoanilines with the 1-(tributylstannyl)-1-substituted allenes affected the successive one-step formation of the 2-methyl-3-substituted indoles. Alternatively, the other type of 2-alkyl-3-substituted indoles could be synthesized in a one-pot operation, which consists of the Stille coupling reaction with the 1-(tributylstannyl)-1,3-disubstituted allenes, followed by TBAF treatment. This procedure could be applied to the synthesis of indomethacin.