87377-65-9

Basic information

• Product Name: benzyl 5-iodo-3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate
• Synonyms: benzyl 5-iodo-3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate
• CAS NO: 87377-65-9
• Molecular Weight: 427.239
• Mol File: 87377-65-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl 5-iodo-3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 5-iodo-3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate(87377-65-9)
• EPA Substance Registry System: benzyl 5-iodo-3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate(87377-65-9)

Safety Data

• Hazardous Substances Data: 87377-65-9(Hazardous Substances Data)

Upstream product

• 87377-63-7 ethyl 4-diethylaminomethyl-3-(ethoxycarbonylmethyl)-5-methylpyrrole-2-carboxylate 
• 54278-18-1 ethyl 3-(ethoxycarbonylmethyl)-4,5-dimethylpyrrole-2-carboxylate 
• 62562-76-9 benzyl 3-(2-hydroxyethyl)-4,5-dimethylpyrrole-2-carboxylate 
• 62562-72-5 benzyl 3-(benzyloxycarbonylmethyl)-4,5-dimethylpyrrole-2-carboxylate 
• 66154-72-1 benzyl 3-(β-acetoxyethyl)-4,5-dimethyl-2-pyrrolecarboxylate 
• 74839-03-5 5-ethoxycarbonyl-4-ethoxycarbonylmethyl-2-methylpyrrole-3-carboxylic acid 
• 87377-64-8 5-benzyloxycarbonyl-4-(2-acetoxyethyl)-3-methylpyrrole-2-carboxylic acid 

Downstream Products

• 87377-72-8 dibenzyl 3'-(2-chloroethyl)-4-(2-acetoxyethyl)-3,4'-dimethylpyrromethane-5,5'-dicarboxylate 
• 87377-71-7 C₃₁H₃₃ClN₂O₅ 
• 87377-66-0 benzyl 3-(2-acetoxyethyl)-4-methylpyrrole-2-carboxylate 

Relevant articles and documents

SYNTHESIS OF BILIVERDIN IXγ (PTEROBILIN)

Condensation of a bis(acetoxyethyl)pyrromethane dicarboxylic acid (11d) with a diformylpyrroketone (12b) afforded a bis(acetoxyethyl)-γ-meso-hydroxyporphyrin (13d) which was converted into the related bis(chloroethyl)-γ-benzoyloxyporphyrin (14f).The Zn complex of the latter was transformed by brief treatment with base, followed by chloromethylethyl ether into the zinc bis(chloroethyl)-γ-ethoxymethoxyporphyrin (20b).Dehydrochlorination with potassium t-butoxide in t-butanol, and acid catalysed demetallation and deprotection then afforded the somewhat unstable blue γ-oxyprotoporphyrin dimethyl ester (21).The Fe-complex of the latter readily underwent oxidative ring opening by aerial oxidation in pyridine, and after demetallation gave biliverdin IXγ (pterobilin) dimethyl ester (22).