873779-32-9

Upstream product

• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 1394030-80-8 (4-hydroxyspiro[chromane-2,4'-piperidine]-1'-yl)-(4-isopropoxy-3-methoxy-phenyl)methanone 
• 1394030-79-5 1'-(4-isopropoxy-3-methoxy-benzoyl)spiro[chromane-2,4'-piperidine]-4-one 
• 1394030-75-1 (R)-benzyl 4-hydroxyspiro[chroman-2,4'-piperidine]-1'-carboxylate 
• 1394030-70-6 benzyl 4-hydroxyspiro-[chroman-2,4'-piperidine]-1'-carboxylate 
• 1394030-05-7 (4-tert-butoxyspiro[chromane-2,4'-piperidine]-1'-yl)-(4-isopropoxy-3-methoxyphenyl)-methanone 
• 1394029-71-0 (4-isopropoxy-3-methoxyphenyl)(4-isopropoxy-3-methylspiro[chroman-2,4'-piperidine]-1'-yl)methanone 
• 1394030-83-1 (4-hydroxy-3-methylspiro[chroman-2,4'-piperidine]-1'-yl)(4-isopropoxy-3-methoxyphenyl)methanone 
• 1394032-29-1 1'-(4-isopropoxy-3-methoxybenzoyl)-3-methylspiro[chroman-2,4'-piperidin]-4-one 
• 1394032-30-4 1'-(4-isopropoxy-3-methoxybenzoyl)-3,3-dimethylspiro[chroman-2,4'-piperidin]-4-one 
• 1394030-82-0 (3-hydroxy-4-isopropoxyspiro[chroman-2,4'-piperidine]-1'-yl)(4-isopropoxy-3-methoxyphenyl)methanone 
• 1394032-28-0 (1a,7b-dihydrospiro[oxireno[2,3-c]chromene-2,4'-piperidine]-1'-yl)(4-isopropoxy-3-methoxyphenyl)methanone 
• 1394030-81-9 (4-isopropoxy-3-methoxy-phenyl)-spiro[chromene-2,4'-piperidine]-1'-yl-methanone 
• 1394029-63-0 (4-isopropoxy-3-methoxy-phenyl)-[4-(2-methylsulfonylethoxy)spiro[chromane-2,4'-piperidine]-1'-yl]methanone 
• 1394030-19-3 (4-isopropoxy-3-methoxy-phenyl)-(4-methoxyspiro[chromane-2,4'-piperidine]-1'-yl)methanone 

Relevant academic research and scientific papers

CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to chroman spirocyclic piperidine amide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE

Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.