87378-73-2Relevant academic research and scientific papers
Diastereoselective Synthesis of Cyclopropane Amino Acids Using Diazo Compounds Generated in Situ
Adams, Luke A.,Aggarwal, Varinder K.,Bonnert, Roger V.,Bressel, Bettina,Cox, Russell J.,Shepherd, Jon,De Vicente, Javier,Walter, Magnus,Whittingham, William G.,Winn, Caroline L.
, p. 9433 - 9440 (2007/10/03)
A simple and high-yielding method for the preparation of cyclopropane amino acids is described. The novel method involves the one-pot cyclopropanation of readily available dehydroamino acids using aryl and unsaturated diazo compounds generated in situ fro
Synthesis of cyclopropane derivatives of aspartic acid by thermal decomposition of substituted pyrazolines
Anisimova,Berkova,Paperno,Deiko
, p. 460 - 463 (2007/10/03)
Thermal decomposition of substituted Δ1- and Δ 2-pyrazolines was used to obtain cyclopropane derivatives of aspartic and adipic acids.
Reaction of 4-Methylene-5(4H)-oxazolones With Diazomethane
Arenal, I.,Bernabe, M.,Alvarez, E. Fernandez,Izquierdo, M. L.,Penades, S.
, p. 607 - 614 (2007/10/02)
The reaction of diazomethane with some (E) and (Z)-2-substituted-4-methylene-5(4)-oxazolones (1a-c) under two different conditions, has been studied. (E) and (Z)-1,2-disubstituted-7-oxo-6-oxa-4-azaspiro-hept-4-enes (3a-c, 4a-c) were mainly obtained, together with multiple addition compounds.The reaction showed to be stereoselective only when the substituents were aromatic.Acid hydrolysis of compounds 3a and 4a produced a mixture of (E) and (Z)-3,5-disubstituted-tetrahydrofuran-2-ones (8a, 9a).Smooth methanolysis of the ring led to (E) and (Z)-1-benzamido-cyclopropanecarboxylic esters (10a-c, 11a-c), which, on acid hydrolysis, gave (E) and (Z)-1-amino-2-phenylcyclopropanecarboxylic acids 12a and 13a.The pmr spectra have been analyzed by an iterative computer method, and the computed best values obtained have been used to deduce the stereochemistry of the spiroderivatives.
