87379-41-7

Usage

Explanation

The molecular formula represents the number of atoms of each element present in a molecule. In this case, the compound has 15 carbon (C), 17 hydrogen (H), 1 nitrogen (N), 2 oxygen (O), and 1 chlorine (Cl) atoms.

Explanation

This describes the specific arrangement of atoms and bonds in the molecule, including the presence of a benzazepine ring, a chlorine atom at the 8th position, and a dihydro-2,5-dione functional group.
3. Heterocyclic compound

Explanation

A heterocyclic compound is a cyclic compound containing atoms of at least two different elements, in this case, carbon, nitrogen, oxygen, and chlorine.
4. Derivative of benzazepine

Explanation

The compound is derived from the benzazepine structure, which is a type of azepine (a seven-membered ring containing nitrogen) with a benzene ring fused to it.
5. Chlorine atom at the 8th position

Explanation

The chlorine atom is attached to the 8th carbon atom in the benzazepine ring, which can influence the compound's reactivity and properties.
6. Dihydro-2,5-dione functional group

Explanation

This functional group consists of two hydrogen atoms and two carbonyl (C=O) groups at the 2nd and 5th positions of the benzazepine ring, which can contribute to the compound's reactivity and properties.
7. Building block in pharmaceutical synthesis

Chemical structure

1H-1-Benzazepine-2,5-dione, 8-chloro-3,4-dihydro-

Upstream product

• 22246-78-2 8-chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one 
• 59868-49-4 8-chloro-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid methyl ester 
• 59868-48-3 methyl N-(3-carbomethoxypropionyl)-4-chloroanthranilate 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 

Downstream Products

• 884196-36-5 8-chloro-1-phenyl-3,4-dihydro-1H-benzo[b]azepine-2,5-dione 
• 1350816-32-8 9-chloro-2-({5-[3-(dimethylamino)propyl]-2-methylphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-34-0 9-chloro-2-({2-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-35-1 9-chloro-2-(5-(3-(dimethylamino)propyl)-2-methoxyphenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 
• 1350816-13-5 9-chloro-2-({3-chloro-5-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione 
• 1350816-54-4 9-chloro-2-({3-[3-(dimethylamino)propyl]-4-fluorophenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-57-7 9-chloro-2-({3-[3-(dimethylamino)propyl]-4-methoxyphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-61-3 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 1350816-65-7 C₂₄H₂₂ClN₅O₂ 
• 1350816-67-9 9-chloro-2-({3-[3-(dimethylamino)propyl]-2-methoxyphenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one 
• 884197-42-6 9-chloro-2-(phenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 
• 1350816-01-1 9-chloro-2-({3-[3-(dimethylamino)propyl]phenyl}amino)-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione 
• 1350815-91-6 9-chloro-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5H-benzo[b]pyrimido[4,5-d]azepin-6(7H)-one 
• 1350815-92-7 4-(9-chloro-6-oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-ylamino)benzamide 

Relevant academic research and scientific papers

5-Substituted 3-chlorokenpaullone derivatives are potent inhibitors of Trypanosoma brucei bloodstream forms

Trypanothione synthetase is an essential enzyme for kinetoplastid parasites which cause highly disabling and fatal diseases in humans and animals. Inspired by the observation that N(5)-substituted paullones inhibit the trypanothione synthetase from the related parasite Leishmania infantum, we designed and synthesized a series of new derivatives. Although none of the new compounds displayed strong inhibition of Trypanosoma brucei trypanothione synthetase, several of them caused a remarkable growth inhibition of cultivated Trypanosoma brucei bloodstream forms. The most potent congener 3a showed antitrypanosomal activity in double digit nanomolar concentrations and a selectivity index of three orders of magnitude versus murine macrophage cells.

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (MLN0905)

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model.

LACTAM COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS

The present invention provides novel compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.

Synthesis of 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones

The syntheses of the 7-phenylpyrimido[5,4-d][1]benzazepin-2-ones 3, 4, and 5 are described. The 7-phenyl group was introduced by phenylation of the lactam nitrogen in 10, 13 and 16 respectively. One of these compounds, 5, showed moderate activity as a CNS agent.