1350816-61-3

Basic information

• Product Name: 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one
• CAS NO: 1350816-61-3
• Molecular Weight: 489.928
• Mol File: 1350816-61-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one(1350816-61-3)
• EPA Substance Registry System: 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepin-6-one(1350816-61-3)

Safety Data

• Hazardous Substances Data: 1350816-61-3(Hazardous Substances Data)

Upstream product

• 7223-38-3 N,N-Dimethylpropargylamin 
• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 59868-49-4 8-chloro-2,5-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid methyl ester 
• 87379-41-7 8-chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2,5-dione 
• 151504-80-2 3-Chloro-4-trifluoromethyl-nitrobenzene 
• 59868-48-3 methyl N-(3-carbomethoxypropionyl)-4-chloroanthranilate 
• 1351438-88-4 di-tert-butyl ((Z)-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}methylylidene)biscarbamate 
• 1350816-60-2 3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)aniline 
• 1350816-59-9 N,N-dimethyl-3-[5-nitro-2-(trifluoromethyl)phenyl]prop-2-yn-1-amine 

Downstream Products

• 1350816-18-0 9-chloro-2-{[3-[3-(dimethylamino)propyl]-4-(trifluoromethyl)phenyl]amino}-5,7-dihydro-6H-pyrimido[5,4-d][1]benzazepine-6-thione 

Relevant articles and documents

Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of polo-like kinase 1 (MLN0905)

This article describes the discovery of a series of potent inhibitors of Polo-like kinase 1 (PLK1). Optimization of this benzolactam-derived chemical series produced an orally bioavailable inhibitor of PLK1 (12c, MLN0905). In vivo pharmacokinetic-pharmacodynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor bearing nude mice. A subsequent efficacy study in nude mice achieved tumor growth inhibition or regression in a human colon tumor (HT29) xenograft model.