873923-25-2

Upstream product

• 127793-62-8 4-((tert-butyldiphenylsilyl)oxy)butanal 
• 141-43-5 ethanolamine 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 130372-07-5 4-(tret-butyldiphenylsilyloxy)butan-1-ol 

Downstream Products

• 923925-83-1 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-benzyl ester 
• 894096-03-8 3-(3-(((9H-fluoren-9-yl)methoxy)carbonylamino)propanamido)-4-((2S,3R,4S,5S,6S)-3,4,5-triacetoxy-6-(methoxycarbonyl)-tetrahydro-2H-pyran-2-yloxy)benzyl 2-(3-(tert-butyldiphenylsilyloxy)propyl)oxazolidine-3-carboxylate 
• 894096-04-9 3-(3-(((9H-fluoren-9-yl)methoxy)carbonylamino)propanarnido)-4-((2S,3R,4S,5S,6S)-3,4,5-triacetoxy-6-(methoxycarbonyl)-tetrahydro-2H-pyran-2-yloxy)benzyl 2-(3-oxopropyl)oxazolidine-3-carboxylate 
• 914773-56-1 3-(3-(((9H-fluoren-9-yl)methoxy)carbonylamino)propanamido)-4-((2S,3R,4S,5S,6S)-3,4,5-triacetoxy-6-(methoxycarbonyl)-tetrahydro-2H-pyran-2-yloxy)benzyl 2-(3-hydroxypropyl)oxazolidine-3-carboxylate 
• 923926-28-7 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyrylamino]-propionylamino}-benzyl ester 
• 873923-28-5 2-(3-Hydroxy-propyl)-oxazolidine-3-carboxylic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-methyl-butyrylamino}-propionylamino)-benzyl ester 
• 923927-90-6 2-(3-Oxo-propyl)-oxazolidine-3-carboxylic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-methyl-butyrylamino}-propionylamino)-benzyl ester 
• 873923-26-3 2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-oxazolidine-3-carboxylic acid 4-(2-amino-propionylamino)-benzyl ester 
• 873923-27-4 2-(3-Hydroxy-propyl)-oxazolidine-3-carboxylic acid 4-[(S)-2-((S)-2-amino-3-methyl-butyrylamino)-propionylamino]-benzyl ester 

Relevant academic research and scientific papers

BETA-GLUCURONIDE-LINKER DRUG CONJUGATES

Ligand Drug conjugate compounds comprising a β-glucuronide-based linker and methods of using such compounds are provided.

Dipeptide-based highly potent doxorubicin antibody conjugates

Highly potent and novel derivatives of doxorubicin were linked to monoclonal antibodies (mAbs) for site-specific drug delivery. Drug linker 5 consisted of a dipeptide linker attached directly to the daunosamine nitrogen of the n-butyldiacetate doxorubicin