873945-31-4

Usage

Uses

Used in Pharmaceutical Development:
3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine is used as a pharmaceutical agent for its potential biological activity. 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine's specific functional groups and structural attributes may contribute to its efficacy in treating certain conditions or diseases, although further research is required to determine its exact therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine serves as a valuable precursor. Its unique structure allows it to be a building block for the creation of more complex molecules, potentially leading to the development of new drugs or other chemical products with specific properties and applications.
Used in Medicinal Chemistry Research:
3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine is utilized in medicinal chemistry research to explore its interactions with biological targets. Understanding how 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine binds to and affects these targets can provide insights into its potential therapeutic uses and help in the design of more effective drugs.
Used in Drug Discovery:
As part of drug discovery processes, 3-Hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyloxy-piperidine is employed to screen for potential drug candidates. Its unique properties may offer new avenues for treating a variety of conditions, making it a significant component in the search for novel therapeutic agents.

Upstream product

• 257928-45-3 (3R,4R,5S)-4-(4-benzyloxyphenyl)-1-(1-phenylethyl)-5-triisopropylsilanyloxy-piperidin-3-ol 
• 873945-33-6 (3R,4R,5S)-4-(4-benzyloxy-phenyl)-1-((R)-1-phenyl-ethyl)-5-triisopropylsilanyloxy-piperidin-3-ol 

Downstream Products

• 944952-84-5 (3R,4R,5S)-4-(4-hydroxyphenyl)-1-(toluene-4-sulfonyl)-5-triisopropylsilanyloxypiperidin-3-ol 
• 912346-39-5 benzyl (3R,4R,5S)-3-hydroxy-5-triisopropylsilanyloxy-4-(4-vinylphenyl)-piperidine-1-carboxylate 
• 873946-14-6 benzyl (3R,4R,5S)-3-hydroxy-4-(4-methoxycarbonylphenyl)-5-triisopropylsilanyl-oxypiperidine-1-carboxylate 
• 912346-47-5 (3R,4R,5S)-4-(4-allyloxy-phenyl)-3-hydroxy-5-triisopropylsilanyloxy-piperidine-1-carboxylic acid benzyl ester 
• 873946-15-7 benzyl (3R,4R,5S)-3-hydroxy-4-(4-trifluoromethanesulphonyloxyphenyl)-5-triisopropylsilanyloxy-piperidine-1-carboxylate 
• 873945-20-1 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-hydroxy-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]-oxazin-6-ylmethoxy]piperidine-1-carboxylate 
• 873946-31-7 4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-3-methanesulphonyloxy-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]-oxazin-6-ylmethoxy]-piperidine-1-carboxylic acid benzyl ester 
• 873946-54-4 3-[4-{4-[1-(3-fluoro-phenyl)pyrrolidin-3-yloxy]-phenyl}-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxy]-propionitrile 
• 873945-22-3 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 873946-53-3 6-{4-{4-[1-(3-fluoro-phenyl)-pyrrolidin-3-yloxy]-phenyl}-5-[2-(1H-tetrazol-5-yl)-ethoxy]-1-(toluene-4-sulfonyl)-piperidin-3-yloxymethyl}-4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazine 
• 873945-23-4 benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate 
• 873945-27-8 (3R,4R,5S)-3-hydroxy-4-(4-hydroxy-phenyl)-5-triisopropylsilanyl-oxy-piperidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Substituted Piperidines as Renin Inhibitors

Compounds of the general formula (I) in which the meanings of the substituents R1, R2, R3, R4, X, Z and n as stated in claim 1 have renin-inhibiting properties and can be used as medicines.

Substituted piperidines as therapeutic compounds

Described are compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R2, R3, W,and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II an

Substituted piperidines as therapeutic compounds

Use of compounds of the general formula (1) and pharmaceutically acceptable salt thereof, in which R1, R2, R3, R4, W, X, Z and n have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

Organic compounds

The present invention relates to substituted piperidines of the general formula (I), where R1, R2, R3, R4, R5, Q and X have the definitions elucidated in more detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors. Moreover, the enzymatic substrate portion of the compound is simultaneously a substrate for a membrane transporter.

SUBSTITUTED 4-PHENYLPIPERIDINES

The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R2, R3, W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.

3,4,5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS

The application relates to novel substituted piperidines of the general formula (II) in which R1, R2', R2'', R4', X, Z, m and n have the meanings defined in the description, to a process for the preparation thereof and to the use of these compounds as medicines, especially as renin inhibitors.