873951-96-3Relevant academic research and scientific papers
Synthesis of IB-01212 by multiple N-methylations of peptide bonds
Nabika, Ryota,Oishi, Shinya,Misu, Ryosuke,Ohno, Hiroaki,Fujii, Nobutaka
, p. 6156 - 6162 (2014)
There are many natural peptides with multiple N-methylamino acids that exhibit potent attractive biological activities. N-methylation of a peptide bond(s) is also one of the standard approaches in medicinal chemistry of bioactive peptides, to improve the
Total solid-phase synthesis of marine cyclodepsipeptide IB-01212
Cruz, Luis J.,Cuevas, Carmen,Canedo, Librada M.,Giralt, Ernest,Albericio, Fernando
, p. 3339 - 3344 (2007/10/03)
A suitable combination of synthetic design, orthogonal protecting groups and coupling reagents was used to complete the first known synthesis of the natural marine cyclodepsipeptide IB-01212. The cyclic, symmetric octapeptide contains two of each of the f
