874013-30-6Relevant academic research and scientific papers
Approaches to the synthesis of enantiopure α-hydroxy-β-lactams with functionalized side chains
Yang, Yan,Wang, Jianmei,Kayser, Margaret
, p. 2021 - 2029 (2007)
We report a synthesis of pharmaceutically important α-hydroxy (or t-butyldimethylsilyl protected α-hydroxy)-β-lactams with functionalized chains in position 4 of the azetidinone ring. A convenient and high-yielding route to these compounds was developed and optimized. Preparation and characterization of several new enantiopure title compounds with various functional groups are discussed.
Copper (I)-catalyzed asymmetric addition of terminal alkynes to β-Imino esters: An efficient and direct method in the synthesis of chiral β3-alkynyl β2,2-dimethyl amino acid derivatives
Wang, Jun,Shao, Zhihui,Yu, Kai Ding Wing Yiu,Chan, Albert S. C.
, p. 1250 - 1254 (2009)
The first catalytic asymmetric addition of terminal alkynes to β-imino esters was carried out using chiral copper(I) complexes as catalysts under mild reaction conditions, providing an efficient and direct synthetic approach to β3-alkynyl βsup
